Increasing the Removal of Protein-Bound Solutes During Extended Hours Hemodialysis
试验速览
- 阶段
- 不适用
- 入组人数
- 24
- 试验地点
- 4
- 主要终点
- Plasma levels of the chemical p-cresol sulfate
研究概览
简要总结
Hemodialysis keeps patients with renal failure alive but does not restore normal health. Retention of chemicals that bind to plasma proteins and are therefore poorly removed by dialysis may contribute to ill health in patients receiving conventional treatment. This proposal will test the effect of a new method designed to improve the removal of protein-bound solutes during dialysis. The effects on blood chemical levels of two different dialysis prescriptions will be tested in patients already undergoing nocturnal in-center hemodialysis three times weekly.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •stable on nocturnal in-center dialysis located close to Stanford University and VA Palo Alto
排除标准
- •recent use of antibiotics
- •gastrointestinal disease
结局指标
主要结局
Plasma levels of the chemical p-cresol sulfate
时间窗: Participants will be followed for 2-3 weeks on different dialysis prescriptions and plasma chemical levels will be measured at the end of this period.
次要结局
未报告次要终点