Effect of Strength Training on Executive Functions in Elderly People With Mild Cognitive Impairment
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Baseline of Inhibitory control
研究概览
简要总结
Cognitive impairment or dementia is their last degree in one of the main concerns at a social level in these ages. To this day, there are different pharmacological and non-pharmacological therapies that can help prevent deterioration, as in this case, physical exercise.
In the existing scientific literature, you can find a lot of information about the effect of aerobic exercise on cognition, but little is known about the effect of force exercise and its effect on general cognition and executive functions.
Therefore, in this research the investigators will investigate the effect of strength training in people over 60 with a diagnosis of mild cognitive impairment in executive functions. For this, a controlled and randomized clinical trial will be developed in the city of Seville
详细描述
The training program will last 20 weeks and a frequency of 3 times / week.
During the week 0 the initial evaluation will be developed. Between weeks 1-20, the training program will be addressed. In week 21, all the changes made in all the measured variables will be evaluated.
Finally, in week 33 the variables will be measured again to see if the possible improvements given in the training program last over time.
The experimental group will perform a planned and individualized training with guided machines and training loads will be adjusted at the beginning of each week.
The control group will perform breathing and relaxation exercises to avoid a sample death.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
After the random assignment of the groups, the coaches will be oblivious to the investigation, so there is no bias.Furthermore, the principal investigator will not know where the data of each group comes from.
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The sample is made up of people over 60 years of age, who are not active professionally, speak and understand the Spanish language.
- •In addition, they should be diagnosed with mild cognitive impairment. This will be evaluated by specialists through the minimental test (score between 24 and 28).
- •On the other hand, they should not suffer from other serious psychiatric or neurodegenerative neurological diseases.
- •In relation to mental health, it will be a reason for exclusion to have had 3 episodes of depression in the last 5 years or 10 episodes that have required some psychiatric or medical treatment.In addition,
- •The people included must be postmenopausal
排除标准
- •Participate in other physical exercise programs in a systematic way or in individualized and systematic programs in cognitive programs.
- •Dispose of cardiovascular diseases, heart diseases that involve an absolute contradiction of physical exercise (unstable angina, severe auroventricular block) and cerebrovascular or have suffered a heart attack in the last 6 years.
- •Have had seizures (More than 2 in the last 12 months).
- •Consumption of alcohol 20 grams / day or 2 beers or wine glasses daily.
- •Functional limitations (According to Functional activities Questionnaire)
- •Being a musician or bilingual.
研究组 & 干预措施
Intervention
THE EXPERIMENTAL GROUP WILL DEVELOP 20 WEEKS OF TRAINING TO IMPROVE THE MUSCLE CAPACITY. FOR THIS, FORCE EXERCISES WILL BE DEVELOPED IN GUIDED MACHINES.
干预措施: Effect of strength training on executive functions in elderly people with mild cognitive impairment. (Other)
Control
THE CONTROL GROUP WILL DEVELOP 20 WEEKS OF BALANCE AND BREATHING EXERCISES.
干预措施: Effect of strength training on executive functions in elderly people with mild cognitive impairment. (Other)
结局指标
主要结局
Baseline of Inhibitory control
时间窗: week 0
To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors. Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory control.
Inhibitory control in the follow-up phase
时间窗: week 33
To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors. Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory controlof words read.
Mean Change from Baseline in Inhibitory control
时间窗: week 21
To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors. Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory controlof words read.
次要结局
- Baseline of general cognition(Week 0)
- Baseline of physical condition variante(week 0)
- General cognition in the follow-up phase(week 33)
- Baseline of physical condition(week 0)
- Baseline of cognitive flexibility(week 0)
- Strength in the follow-up phase(week 33)
- Mean Change from Baseline in General cognition(week 21)
- Mean Change from Baseline in Physical condition(week 21)
- Mean Change from Baseline in Physical condition variante(week 21)
- Baseline of strength(week 0)
- Mean Change from Baseline in cognitive flexibility variante(week 21)
- Physical condition in the follow-up phase(week 33)
- Physical condition variante in the follow-up phase(week 33)
- Baseline of blood test(week 0)
- Mean Change from Baseline in Blood test(week 21)
- Mean Change from Baseline in Strength(week 21)
- Mean Change from Baseline in cognitive flexibility(week 21)
- cognitive flexibility in the follow-up phase(week 33)
- Baseline of cognitive flexibility variante(week 0)
- cognitive flexibility variante in the follow-up phase(week 33)
- Mean Change from Baseline in working memory(week 21)
- Baseline of working memory(week 0)
- Working memory in the follow-up phase(week 33)
研究者
Manuel Jesús
Science of physical activity and sport
University of Seville