Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Modified Rankin Scale (mRS)
研究概览
简要总结
Early rehabilitation is feasible for stroke patients is still under debate. In addition, IA thrombectomy has been a new treatment for the past few years and currently no known research exploring the efficacy of very early rehabilitation after thrombectomy, or any possible rehabilitation-related adverse effects. Therefore, in this study, the investigators will investigate the effectiveness of earlier rehabilitation intervention after IA thrombectomy for cerebral large vessel occlusion based on functional independence.
详细描述
The study will be the prospective randomized controlled trial, where patients eligible for inclusion will be randomly assigned to earlier rehabilitation group or control group. The investigators will analyze the correlation between frequency/intensity of rehabilitation and primary/secondary outcomes. Dose-response analysis for earlier rehabilitation will be performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cerebral stroke due to infarction of large vessels in the anterior circulation, including internal carotid artery (, middle cerebral artery (MCA) M1 or M2 segment, anterior cerebral artery (ACA) A1 segment
- •Receive arterial thrombectomy (IA thrombectomy)
- •Stable vital signs include heartbeat less than 130 bpm, systolic blood pressure less than 180mmHg, blood oxygen SpO2 >92%
- •No use of pressors, oxygen masks or respirators after arterial thrombectomy
排除标准
- •Posterior circulation large vessel stroke
- •Functional score (mRS) ≥ 3 points before the stroke
- •Other contraindications for rehabilitation treatment
- •Neurosurgery immediately after this stroke
- •Those who cannot receive rehabilitation within one week of stroke due to serious medical problems
- •After the stroke, two specialists judged the end of life and arranged palliative and palliative treatment
结局指标
主要结局
Modified Rankin Scale (mRS)
时间窗: 3rd months after stroke
Modified Rankin Scale (mRS) at 3rd months after stroke:6 grades(higher grades means more disability)
次要结局
- Barthel Index(1st and 3rd months after stroke)
- Fugl-Meyer Assessment(1st and 3rd month after stroke)
- Modified Rankin Scale (mRS)(1st months after stroke)