A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON) - D5087C00001

AstraZeneca AB0 个研究点目标入组 327 人开始时间: 2024年6月14日最近更新: 2024年8月21日

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•Provision of signed and dated written ICF prior to any mandatory and non-mandatory study-specific procedures, sampling and analyses., ECOG performance status of 0 or 1., Participant must be =18 years (= 19 years of age in South Korea) at the time of signing the informed consent. All genders are permitted., Histologically or cytologically confirmed locally advanced or metastatic NSCLC which is not amenable to curative therapy., Must have at least one documented sensitising EGFR mutation: exon19 deletion, L858R mutation, and/or T790M., Documented radiologic progression on first- or second-line treatment with osimertinib as the most recent anti-cancer therapy., Mandatory provision of FFPE tumour tissue., MET overexpression and/or amplification in tumour specimen collected following progression on prior osimertinib treatment., Measurable disease as defined by RECIST 1.1., Adequate haematological, liver, renal and cardiac functions, and coagulation parameters.

•Squamous NSCLC, and small cell lung cancer., Receipt of live attenuated vaccine (including against COVID-19) within 30 days prior to the first dose of study intervention., Past medical history of ILD, drug-induced ILD, radiation pneumonitis, which required steroid treatment, or any evidence of clinically active ILD., Participants currently receiving medications or herbal supplements known to be strong inducers of cytochrome P450 (CYP)3A4 or strong inhibitors of CYP1A2., Prior or current treatment with a third-generation EGFR-TKI other than Osimertinib., Prior or current treatment with savolitinib or another MET inhibitors., Spinal cord compression or brain metastases, unless asymptomatic and are stable., History or active leptomeningeal carcinomatosis., Unresolved toxicities from any prior therapy greater than CTCAE Grade 1 and prior platinum-therapy related Grade 2 neuropathies with the exception of alopecia and haemoglobin = 9.0 g/dL., Active/unstable cardiac diseases currently or within the last 6 months, clinically significant ECG abnormalities, and/or factors/medications that may affect QTc intervals., History of liver cirrhosis of any origin and clinical stage; or history of other serious liver disease or chronic disease with relevant liver involvement., Known serious active infection including, but not limited to, tuberculosis, or HIV, HBV or HCV or gastrointestinal disease.

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