NL-OMON40980已完成不适用
Does oral administration of dabigatran etexilate, a direct thrombin inhibitor, achieve clinical significant concentrations of dabigatran and thrombin inhibiting activity in vitreous and subretinal fluid? - Dabigatran & Ocular Accessibility
Oogziekenhuis Rotterdam0 个研究点目标入组 24 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Age >= 18 years,
- •- Informed consent,
- •- Needing surgery for a rhegmatogenous retinal detachment (scleral buckle surgery or vitrectomy)
排除标准
- •- Using other anticoagulants (e.g. acenocoumarol, heparin etc),
- •- Using medication that increases risk of GI bleeding (e.g. aspirin, NSAID*s, SSRI*s, oral corticosteroids).
- •- History of stomach ulcer/ bleeding
- •- Patients with renal function (CrCL) < 50 mL/min,
- •- Age > 75
- •- Hepatic impairment,
- •- Hypersensitivity to the active substance or to any of the excipients,
- •- Concomitant treatment with systemic ketoconazole, cyclosporine, itraconazole, tacrolimus and dronedarone,
- •- Lesion or condition at significant risk of major bleeding.
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