The Effect of Metformin and Medroxyprogesterone Acetate on Apoptotic Signaling Pathways in Wistar-Albino Rats With Induced Endometrial Hyperplasia
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Caspase-9 Expression Levels in Rat Uterine Tissue
研究概览
简要总结
The purpose of the study is to determine apoptotic signaling pathways such as Survivin, Bcl-2, Bax, c-Myc and caspase-9 expression levels in rats model with iatrogenic endometrial hyperplasia after metformin and medroxyprogesterone acetate administration.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 8 Weeks 至 10 Weeks（Child）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Control group
Medicated with only 4mg/kg 17β estradiol hemihydrate for 20 days to develop endometrial hyperplasia
干预措施: 17β estradiol hemihydrate (Drug)
Metformin group
Having been obtained hyperplasia, the investigators continued medication with 50 mg/kg metformin in addition to 17β estradiol hemihydrate for 10 days
干预措施: 17β estradiol hemihydrate (Drug)
Metformin group
Having been obtained hyperplasia, the investigators continued medication with 50 mg/kg metformin in addition to 17β estradiol hemihydrate for 10 days
干预措施: Metformin (Drug)
Medroxyprogesterone acetate group
Having been obtained hyperplasia, the investigators continued medication with 1mg/day medroxyprogesterone acetate in addition to 17β estradiol hemihydrate for 10 days
干预措施: 17β estradiol hemihydrate (Drug)
Medroxyprogesterone acetate group
Having been obtained hyperplasia, the investigators continued medication with 1mg/day medroxyprogesterone acetate in addition to 17β estradiol hemihydrate for 10 days
干预措施: medroxyprogesterone acetate (Drug)
结局指标
主要结局
Caspase-9 Expression Levels in Rat Uterine Tissue
时间窗: 4 months
Bcl-2 Gene Expression Levels in Rat Uterine Tissue
时间窗: 4 months
Bax Gene Expression Levels in Rat Uterine Tissue
时间窗: 4 months
Survivin Gene Expression Levels in Rat Uterine Tissue
时间窗: 4 months
c-Myc Gene Expression Levels in Rat Uterine Tissue
时间窗: 4 months
次要结局
未报告次要终点
研究者
Erdem Sahin
Principal Investigator
Kayseri Education and Research Hospital