A Randomized Trial of Digital Interventions to Increase HPV Vaccination Intentions Among Nigerian Caregivers
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,340
- 试验地点
- 1
- 主要终点
- HPV Vaccination Intention (1-Week Post-Intervention)
研究概览
简要总结
This study evaluates whether different types of digital health communication can increase parents' intention to vaccinate their daughters against human papillomavirus (HPV) in Nigeria. HPV vaccination is recommended for girls aged 9-14 years and helps prevent cervical cancer, yet vaccination rates remain low.
Parents of eligible, unvaccinated girls will be randomly assigned to receive one of several types of digital content delivered online. These include: (1) a short chatbot conversation based on motivational interviewing principles, (2) an interactive game designed to help parents recognize and resist common forms of vaccine misinformation, (3) a set of short edutainment videos about HPV vaccination, (4) standard informational infographics about HPV vaccination from a national public health agency, or (5) unrelated health content about menstruation.
The main outcome is parents' self-reported intention to vaccinate their daughter against HPV, measured immediately and one week after exposure to the assigned content. Additional outcomes include HPV-related knowledge, perceptions of vaccine safety, willingness to recommend the vaccine to others, and self-reported vaccine uptake at 1-week and 6 month follow-up. The results will help inform scalable communication strategies to improve HPV vaccination uptake in low- and middle-income settings.
详细描述
Cervical cancer remains a leading cause of cancer-related mortality among women in Nigeria. Persistent infection with high-risk types of human papillomavirus (HPV) is the primary cause of cervical cancer, and safe, effective vaccines are available and recommended for girls aged 9-14 years. Despite national and global efforts to expand access, HPV vaccination coverage in Nigeria remains low. Parental hesitancy, misinformation, limited knowledge, and lack of engagement with existing health communication materials are key barriers.
This randomized controlled trial examines whether different forms of digital communication can increase HPV vaccination intention among parents of unvaccinated, vaccine-eligible girls in Nigeria. The study focuses on scalable, low-cost interventions that could be deployed through mobile phones and other digital platforms.
Eligible participants are parents or primary caregivers of at least one unvaccinated girl aged 9-14 years. Participants will be individually randomized in equal proportions to one of five conditions:
A motivational interviewing-style chatbot that provides brief, interactive counseling adapted from World Health Organization vaccination guidance.
A short interactive "pre-bunking" game designed to build resistance to common forms of HPV vaccine misinformation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 27 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Parent or primary caregiver of at least one girl aged 9-14 years
- •Parent states "no" or "unsure" to question asking if eligible daughter has received any doses of the HPV vaccine
- •Provides informed consent to participate
排除标准
- •Parent or caregiver of a girl who has already received one or more doses of the HPV vaccine
- •Does not meet age eligibility criteria for an eligible daughter
- •Fails Attention Checks
研究组 & 干预措施
Misinformation-resistance pre-bunking inoculation arm
A short interactive game (approximately 3-5 minutes) designed to build resistance to HPV vaccine misinformation
干预措施: Misinformation-resistance pre-bunking inoculation (Behavioral)
Unrelated content control arm
Series of infographics on menstruation from Nigeria's Menstrual Health Advocacy Consortium
Standard infographic control arm
Existing infographics on HPV vaccination from Nigeria's National Primary Health Care Development Agency (NPHCDA)
干预措施: Standard infographic control (Behavioral)
Chatbot counseling arm
A brief motivational-interviewing-style chatbot dialogue adapted from WHO vaccination counseling guidance
干预措施: Chatbot counseling (Behavioral)
Short edutainment arm
5-6 brief edutainment videos (total viewing time approximately 10-15 minutes) providing HPV vaccine information tailored to the Nigerian context
干预措施: Short edutainment (Behavioral)
结局指标
主要结局
HPV Vaccination Intention (1-Week Post-Intervention)
时间窗: 1 week after exposure to the assigned intervention content
Parent's self-reported intention to vaccinate their selected daughter (aged 9-14 years) against HPV, measured on a 10-point numeric scale, where higher values indicate greater intention to vaccinate. If a participant has more than one eligible daughter, one daughter is randomly selected for all outcome questions.
HPV Vaccination Intention (Immediately Post-Intervention)
时间窗: Immediately Post-Intervention
Parent's self-reported intention to vaccinate their selected daughter against HPV, measured on a 10-point numeric scale.
次要结局
- HPV Vaccination Intention (6 months post-intervention)(6 months post-intervention)
- Self-Reported HPV Vaccine Uptake(6 months post-intervention)
- Perceived Safety of the HPV Vaccine(1 week post-intervention, 6 months post-intervention)
- Likelihood of Recommending the HPV Vaccine to Other Parents(1 week post-intervention, 6 months post-intervention)
- Self-Reported Knowledge of the HPV Vaccine(1 week post-intervention, 6 months post-intervention)
- Knowledge of the Protective Effects of the HPV Vaccine(1 week post-intervention, 6-months post-intervention)
- Knowledge of Cervical Cancer Detection Methods(1 week post-intervention, 6 months post-intervention)
- Knowledge of HPV Vaccine Eligibility(1 week post-intervention, 6 months post-intervention)
- Perceived Support of HPV Vaccine(1 week post-intervention, 6 months post-intervention)
- Attitudes towards HPV Vaccine(1 week post-intervention, 6 months post-intervention)
- Self-reported Information-seeking behaviors(6 months post-intervention)
- Objective information-seeking behavior(6 months post-intervention)