Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Pressure Pain Thresholds
研究概览
简要总结
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 18-70
- •Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
- •Fulfills the 2010 ACR-EULAR classification criteria for RA
- •Healthy volunteers: No significant pain/fatigue/depression/anxiety.
排除标准
- •Advanced liver, kidney or cardiovascular disease
- •Neuropathic pain
研究组 & 干预措施
Fibromyalgia
Participants who fulfill the 1990 and 2011 American College of Rheumatology Criteria for FM.
Rheumatoid Arthritis
Participants who fulfill the 2010 American College of Rheumatology (ACR)-European League against rheumatism (EULAR) classification criteria for RA.
Healthy Volunteers
Participants who do not have significant pain/fatigue/anxiety/depression.
结局指标
主要结局
Pressure Pain Thresholds
时间窗: One hour
Using an algometer pressure pain thresholds will be obtained several times at the upper and lower extremities
次要结局
未报告次要终点