Survival Nomogram for Patients With Thymic Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
Background Thymic carcinoma (TC) is a rare and aggressive mediastinal malignancy with poor prognosis. Our study aimed to develop a nomogram to predict overall survival (OS) of TC patients.
Method A total of 156 patients confirmed TC between 1996 and 2023 were selected from our database. They were divided into training cohort, validation cohort one and validation cohort two. A nomogram was constructed based on the risk factors affecting prognosis using a Cox proportional hazards regression model. The discrimination and calibration of the nomogram were evaluated by C-index, AUC and curve of calibration. The three cohorts were divided into low-risk and high-risk subgroups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The diagnosis of TC in patients should be confirmed through endoscopic tumor biopsy or surgery to obtain tumor tissue for pathological confirmation under light microscope, and even further confirmed through immunohistochemical staining.
- •Patients should accept surgery and obtain complete postoperative pathological reports in order to assess Masaoka-Koga staging.
- •Patients who accepted surgery should be followed up at least six months or reached the endpoint event.
排除标准
- •The patient had two types of primary tumors concurrently including TC.
- •The tumor in the thymus was not primary but metastatic, having originated from a different primary site.
- •The patient did not obtain a complete pathological report after surgery.
结局指标
主要结局
Overall survival
时间窗: From date of accepting surgery until the date of final documented or date of death from any cause, whichever came first, assessed up to 325 months
Overall survival (OS) is the length of time a patient lives after a diagnosis or the start of treatment for a disease, such as cancer
次要结局
未报告次要终点
研究者
Weijie Ye
Resident Doctor
Sun Yat-sen University