NCT01075776撤回不适用
The Effects of C-type Natriuretic Peptide on Endothelial Function Following Ischaemia-Reperfusion in the Human Forearm
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Change in area under curve dose-response to acetylcholine after IR injury
研究概览
简要总结
To determine the effects of whether increasing CNP concentrations slightly above normal will improve the functioning of blood vessels after the interruption in the flow of blood. In this study we are looking at the function of the blood vessels of the forearm, as a substitute for those in the heart
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy human volunteers on no systemic medication, excepting the oral contraceptive pill
排除标准
- •History of medical illness
- •Unwillingness to sign consent form
- •Use of non-OCP medications
- •Hypertension on examination of the blood pressure
研究组 & 干预措施
CNP
Experimental
Infusion of CNP prior to IR injury
干预措施: Acetylcholine (Drug)
CNP
Experimental
Infusion of CNP prior to IR injury
干预措施: C-type natriuretic peptide (CNP) (Drug)
Saline
Placebo Comparator
Effect of saline infusion prior to IR injury
干预措施: Saline (Drug)
Saline
Placebo Comparator
Effect of saline infusion prior to IR injury
干预措施: Acetylcholine (Drug)
结局指标
主要结局
Change in area under curve dose-response to acetylcholine after IR injury
时间窗: 2h
次要结局
未报告次要终点
研究者
Amrita Ahluwalia
Professor of Vascular Pharmacology
Queen Mary University of London
研究点 (1)
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