A Trial of Adding Lung Protective Strategies to Existing Enhanced Recovery After Surgery (ERAS) Protocols and Its Effects on Improving Post-Operative Lung Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Inspiratory Capacity
研究概览
简要总结
The objective of this study is to determine whether the addition of lung protective strategies to existing enhanced recovery after surgery (ERAS) protocols for colorectal surgeries and hepatobiliary surgeries will improve post-operative lung function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All subjects going for scheduled colorectal or hepatobiliary surgery at the MUSC ART hospital who would normally be utilizing the existing ERAS protocols
- •English speaking
- •Able to give informed consent
- •Ages 18 years and older
排除标准
- •Emergency cases
- •Pregnant subjects-confirmed by pre-operative urine pregnancy test
- •Subjects with unique lung pathologies including, but not limited to: advanced pulmonary fibrosis, lung transplantation recipients, end stage COPD, pulmonary Hypertension
- •Subjects on home O2
研究组 & 干预措施
Standard Enhanced Recovery After Surgery (ERAS) Protocol
Control for this study will be the standard MUSC ERAS protocol - fluid intake, hydration, anti-emetics, pain control, and several other considerations.
干预措施: Standard Enhanced Recovery After Surgery (ERAS) Protocol (Procedure)
ERAS and 5 Lung Protective Interventions
The standard MUSC ERAS protocol - fluid intake, hydration, anti-emetics, pain control, and several other considerations. The subject will also receive the following lung protective interventions:
- Pressure control ventilation-volume guaranteed (PCV-VG) ventilation at approximately 7cc/kg of predicted body weight (derived from combination of sex and height)
- Positive end-expiratory pressure (PEEP) 7cm H2O5
- Immediately post intubation recruitment breath (30cm water for 30 seconds)
- Every 1 hour recruitment breath (30cm water for 30 seconds)
- 40% FIO2 initially - titrate up as necessary to maintain SPO2 >94%
干预措施: ERAS and 5 Lung Protective Interventions (Procedure)
结局指标
主要结局
Inspiratory Capacity
时间窗: 2 hours
The primary outcome of interest is the inspiratory capacity obtained in the PACU via the incentive spirometer.
次要结局
- Oxygen Saturation (SPO2) Trends(2 hours)
- Incidence of Supplemental Oxygen Requirements(2 hours)
研究者
David Gutman
Assistant Professor
Medical University of South Carolina