Impact of Regular Physical Activity in Normal-Weight Individuals With Type 2 Diabetes and Abdominal Obesity: Nationwide Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 249,247
- 主要终点
- Major adverse cardiac and cerevrovascular events (MACCE)
研究概览
简要总结
Individuals with T2DM accompanied by abdominal obesity tend to experience worse clinical outcomes. To identify modifiable factors that may improve these outcomes, the investigators conducted a retrospective cohort study using data from the Korean National Health Insurance Service (K-NHIS) database to evaluate the impact of regular physical activity.
详细描述
It is well established that patients with T2DM and abdominal obesity have worse clinical outcomes. This holds true even among individuals with a normal body weight but central (abdominal) obesity. In this study, the investigators aimed to determine whether engaging in regular physical activity (defined as vigorous exercise at least three times per week) is associated with improved clinical outcomes in normal-weight individuals with abdominal obesity. Specifically, we compared the incidence of MACCE between normal-weight patients with type 2 diabetes who had abdominal obesity and those who did not.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who were newly diagnosed with T2DM and had a normal body weight at the time of diagnosis.
排除标准
- •Patients with any pre-existing diabetes-related complications
- •Patients who were overweight or obese based on BMI criteria
结局指标
主要结局
Major adverse cardiac and cerevrovascular events (MACCE)
时间窗: 10 years after diagnosed T2DM
Composite of all-cause death, myocardial infarction, ischemic stroke, heart failure
次要结局
- All cause death(10 years after diagnosed T2DM)
- myocardial infarction(10 years after diagnosed T2DM)
- Ischemic stroke(10 years after diagnosed T2DM)
- Heart failure(10 years after diagnosed T2DM)
研究者
Ki Hong Choi
Professor
Samsung Medical Center