Impact of Juvenile Obesity on Emotional Memory and Functional Connectivity Between the Amygdala and the Hippocampus
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- the level of connectivity between the amygdala and the hippocampus recorded during the execution of an emotional memory task in the scanner.
研究概览
简要总结
Recent studies indicate that obese teenagers exhibit memory disturbances. Adolescence represents a crucial period in the development of the hippocampus and the amygdala, necessary for the implementation of memory and emotional functions for the rest of life. Disturbances of the interaction between amygdala and hippocampus during adolescence have been associated with the development of neuropsychiatric disorders. However, the impact of juvenile obesity on functional amygdala-hippocampus connectivity has not been evaluated yet. The main objective of this study is to compare the emotional memory performance and the level of functional connectivity between the hippocampus and the amygdala during the realization of an emotional associative memory task, in obese and control adolescents.
详细描述
Obesity increases the prevalence of cognitive impairment. In particular, it can promote disturbances of contextual memory dependent on the hippocampus. Obesity is also associated with negative emotional consequences. However, no clinical study has so far evaluated the effect of obesity on emotional memory, a function underpinned by the amygdala. Recent studies indicate that obese children and adolescents exhibit memory disturbances. Adolescence represents a crucial period in the development of the hippocampus and the amygdala, two brain regions implicated in memory and emotional functions for the rest of life. Changes in connectivity during development, whether structural or functional, are major before the age of 10 and progressive and minor until the age of 30. Disturbances of this amygdala-hippocampal functional connectivity during adolescence have been associated with the development of neuropsychiatric disorders. However, the impact of childhood obesity on functional amygdala-hippocampus connectivity has still not been evaluated. The first aim of the study is to compare the functional connectivity of the hippocampus and the amygdala measured during the realization of an emotional associative memory task or at rest before and after the task between obese teenagers and control teenagers and how closely it is related to emotional memory performances. Secondly, it will be determined whether the level of functional connectivity between the hippocampus and the amygdala is related to cognitive performances and eating symptomatology in obese teenagers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 17 Years（Child）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Experimental group: 12-17 years old boys, BMI>30 (according to IOTF), right-handed, French secondary school, beneficiary of social security, consent of the holders of parental authority.
- •Control group: 12-17 years old boys, BMI<25 (according to IOTF), right-handed, French secondary school, beneficiary of social security, consent of the holders of parental authority.
排除标准
- •Adolescent with pubertal stage of Tanner <2
- •Adolescent with known visual or auditory difficulties
- •Adolescent with a known chronic pathology requiring medication
- •Adolescent with psychotic, neurodevelopmental or substance use disorder
- •Adolescent who may have a contraindication to the MRI examination (presence in the body of metallic prostheses, pacemaker, metal chips, claustrophobia).
研究组 & 干预措施
experimental group
Thirty obese boys (12-17 years old) undergoing an MRI, a clinical and psychological examination and a series of cognitive tests
干预措施: an MRI examination (Behavioral)
control group
Thirty healthy boys (12-17 years old) paired for pubertal stage, level of education and socio-economic level undergoing an MRI, a clinical and psychological examination and a series of cognitive tests
干预措施: an MRI examination (Behavioral)
结局指标
主要结局
the level of connectivity between the amygdala and the hippocampus recorded during the execution of an emotional memory task in the scanner.
时间窗: through study completion, an average of 24 months
The level of connectivity between the hippocampus and the amygdala during the performance of the task will be measured through the fluctuations of the blood oxygen level-dependent (BOLD) signal obtained in activation functional magnetic resonance imaging (fMRI) during the performance of an associative emotional memory task. The level of functional connectivity between two brain regions will be deduced from the temporal correlation between the fluctuations of the BOLD signal between these two regions. This coefficient will be normalized in Z-score before analysis.
次要结局
- The score at the emotional memory task performed in the scanner will be collected(through study completion, an average of 24 months)
- The level of connectivity between the amygdala and the hippocampus before and after the task will also be recorded at rest.(through study completion, an average of 24 months)
- The percentage of body fat(through study completion, an average of 24 months)
- " Verbal Recall/Recognition Memory Task " administrated through the CANTAB neuropsychological examination(through study completion, an average of 24 months)
- Percentage of correct and incorrect responses at the " Emotion Recognition Task " administrated through the CANTAB neuropsychological examination(through study completion, an average of 24 months)
- Number of correct or incorrect responses at the " Emotion Recognition Task " administrated through the CANTAB neuropsychological examination(through study completion, an average of 24 months)
- Response latencies at the " Emotion Recognition Task " administrated through the CANTAB neuropsychological examination(through study completion, an average of 24 months)
- cognitive functioning of the adolescent(through study completion, an average of 24 months)
- grey matter volumes (mm3)(through study completion, an average of 24 months)
- cortical thicknesses (mm)(through study completion, an average of 24 months)
- " Paired Associates Learning Task " administrated through the CANTAB neuropsychological examination(through study completion, an average of 24 months)
- the number of distinct words for the free-recall phase (" Verbal Recall/Recognition Memory Task " administrated through the CANTAB neuropsychological examination)(through study completion, an average of 24 months)