Pilot study on the determination of therapy resistant areas within the tumor in patients with high-grade glioma by repeated 18F-FDG-PET-CT scans. - PET-CT high-grade glioma

MAASTRO clinic0 个研究点目标入组 10 人开始时间: 待定最近更新: 2024年5月13日

适应症

试验速览

暂无简介。

•Histologically confirmed gliomas III - IV (glioblastoma, anaplastic astrocytoma, gliosarcoma) at primary diagnosis
•WhO PFS <= 2
•Tumours which do enhance on pre-operative imaging.
•Post-operative enough visible residual tumour on PET or status after biopsy only
•Age >18 years
•Availability of deep fresh frozen tissue for molecular biologic evaluation - if possible
•Patient able to tolerate full course of conventional RT and follow serial scanning
•No previous radiotherapy to the head and neck and brain area.
•Prior neurosurgery within 6 weeks of treatment
•No previous chemotherapy before treatment of the glioma. Standard radiochemotherapy with temozolomide is not excluded
•No prior or concurrent medical condition which would make treatment difficult to complete. Medication with steroids is allowed.
•No incapacitated patients.

•No Histologically confirmed gliomas II - IV (glioblastoma, anaplastic astrocytoma, gliosarcoma) at primary diagnosis;
•WHO PFS >2
•Tumours which do not enhance on pre-operative imaging.
•Post-operative not enough visible resiudal tumor on PET or status after biopsy only
•Age < 18 years
•Patient is not able to tolerate full course of conventional RT and follow serial scanning
•Previous radiotherapy to the head and neck and brain area.
•Prior neurosurgery not within 6 weeks of treatment
•Previous chemotherapy before treatment of the glioma.
•Prior or concurrent medical condition which would make treatment difficult to complete.
•Incapacitated patients.

发起方