临床试验/NCT02888496

NCT02888496已完成不适用

Caractérisation Des Anomalies Immunologiques au Cours de la Pseudopolyarthrite rhizomélique et Effets du Traitement Par Tocilizumab

University Hospital, Brest1 个研究点分布在 1 个国家目标入组 40 人开始时间: 2015年1月最近更新: 2016年9月5日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方: University Hospital, Brest
入组人数: 40
试验地点: 1
主要终点: Proportion of blood lymphocyte populations (T cells, B cells, NK cells)

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Pathophysiology of polymyalgia rheumatica (PMR) is ill defined. This study aims at characterizing immunological abnormalities in PMR patients, and to assess the effects of tocilizumab therapy on this abnormalities.

详细描述

Comparison of PMR patients and matched control subjects.

研究设计

研究类型: Observational
观察模型: Case Control
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 85 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•PMR patient included in the TENOR study with samples available

排除标准

•Patient not included in the TENOR study

研究组 & 干预措施

PMR patients

Patients included in the clinical trial TENOR (prospective open-labeled study of tocilizumab in treatment-naïve PMR patients)

干预措施: tocilizumab (Drug)

结局指标

主要结局

Proportion of blood lymphocyte populations (T cells, B cells, NK cells)

时间窗: 6 months

Lymphocyte subset analysis by flow cytometry

次要结局

Serum cytokine concentration measurement(6 months)

研究者

发起方

University Hospital, Brest

申办方类型

Other

责任方

Sponsor

研究点 (1)

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