Impact of Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Incidence of ischemia- driven revascularization
研究概览
简要总结
This study aims to evaluate the impact of the triglyceride-glucose (TyG) index on the angiographic profiling of non-diabetic patients with premature coronary artery disease (CAD).
详细描述
Premature coronary artery disease (CAD), defined as CAD occurring before the age of 55 in men and 65 in women, has emerged as a growing health concern worldwide.
Insulin resistance and associated metabolic alterations are strongly implicated in premature atherosclerosis. Even in non-diabetic individuals, subclinical insulin resistance promotes endothelial dysfunction, oxidative stress, and low-grade inflammation, leading to early vascular damage.
The triglyceride-glucose (TyG) index, calculated using fasting glucose and triglyceride levels, has emerged as a cost-effective surrogate marker for insulin resistance.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old.
- •Both sexes.
- •Non-diabetic patients [no history of diabetes, hemoglobin A1C (HbA1C) < 6.5%, fasting glucose < 126 mg/dL].
- •Confirmed diagnosis of coronary artery disease (CAD) by coronary angiography.
排除标准
- •Known diabetes mellitus (type 1 or type 2).
- •Previous history of coronary revascularization.
- •Severe hepatic or renal dysfunction [alanine transaminase (ALT)/aspartate aminotransferase (AST) ≥ 5× upper limit of normal (ULN), estimated glomerular filtration rate (eGFR)< 30 mL/min/1.73 m²].
- •Malignant disease, autoimmune disease, or systemic inflammatory disorders.
- •Current use of triglyceride-lowering medications.
结局指标
主要结局
Incidence of ischemia- driven revascularization
时间窗: 6 months post-procedure
Incidence of ischemia- driven revascularization will be recorded.
次要结局
- Association between triglyceride-glucose index and single-vessel disease(6 months post-procedure)
- Association between triglyceride-glucose index and two-vessel disease(6 months post-procedure)
- Association between triglyceride-glucose index and three-vessel disease(6 months post-procedure)
- Correlation of the triglyceride-glucose index with traditional cardiovascular risk factor(6 months post-procedure)
研究者
Remon Saleh Adly
Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.
Sohag University