Cereal or Grain Consumption and Gastric Cancer Risk: a Systematic Review and Meta-analysis of Observational Studies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- the relationship between overall cereal consumption and gastric cancer occurance
研究概览
简要总结
This project involved a systematic literature review of published trials of cereal or grain in relation to the risk of gastric cancer. Data was extracted from the publications on PubMed, EMBASE, Cochrane Library.A traditional meta-analysis, subgroup analysis, and heterogeneity was conducted on the extracted data.
详细描述
Investigators searched PubMed, EMBASE, Cochrane Library for studies focusing on cereal or grain in relation to the risk of gastric cancer up to October 2017. Summary odd ratios (OR) and 95% confidence intervals (CI) were calculated by using either random effect models or fixed effect models according to the heterogeneity of included studies. Subgroup analysis, heterogeneity, and publication bias were also performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •a case-control studies or a cohort study
- •investigate the association between cereal or grain intake and GC occurrence
- •report an odds ratio (OR) or relative risk (RR) with corresponding 95% confidence intervals (CI)
- •provide sufficient data to estimate OR or RR
排除标准
- •Non-human studies
- •GC mortality-based cohort studies
结局指标
主要结局
the relationship between overall cereal consumption and gastric cancer occurance
时间窗: up to 2 years
perform a pooled analysis of included studies with OR through STATA 12.0
次要结局
- the relationship between whole grain and gastric cancer occurance(up to 2 years)
- the relationship between other grain and gastric cancer occurance(up to 2 years)
- the relationship between refined grain and gastric cancer occurance(up to 2 years)
研究者
Yong Zhou
associate chief physician
West China Hospital