Diuretic Efficacy of Dexamethasone in Congestive Heart Failure Patients
试验速览
- 阶段
- 1 期
- 状态
- 暂停
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- glomerular filtration rate (calculated by Cockroft and Gault formula).
研究概览
简要总结
The purpose of this study is to determine whether glucocorticoids have potent diuretic effects in patients with congestive heart failure.
详细描述
Glucocorticoids are known to have pronounced physiological effects in the kidney. Conventional teaching dictates that it should be used with caution in patients with congestive heart failure due to its fluid and sodium retention effects. Surprisingly, despite the widespread prevalence of this belief within the medical community, there are few data to support it. In fact, several small animal studies have documented its striking diuretic effects due to increased renal plasma flow and glomerular filtration rate without changes in the glomerular filtration fraction. We design this study to determine whether glucocorticoids have a potent diuretic effect in patients with heart failure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Congestive heart failure patients due to any cause
- •Patients with normal cortical function
- •Congestive heart failure patients who are on diuretic therapy
- •Clinically stable and body weight maintained the same for at least 3 days without signs of fluid retention
排除标准
- •Patient refusal
- •Signs of infection
结局指标
主要结局
glomerular filtration rate (calculated by Cockroft and Gault formula).
urine volume
urine electrolyte excretion (urine sodium, urine potassium, urine chloride), and urine creatinine.
serum electrolyte (serum sodium, serum potassium, serum chloride), serum creatinine, serum urea, serum uric Acid.
fractional sodium excretion
次要结局
未报告次要终点