Study of Immuno-regulatory Mechanisms Induced by Hookworm Infection
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Amount and phenotype of Treg
研究概览
简要总结
The main objective of this study is to characterize the regulatory immune response induced by hookworm in an infected Vietnamese rural population from the periphery of HCM, evolution after infection treatment and during potential naturally reinfection.
详细描述
Population: 20 healthy adults (18-65 years) infected and non infected by Hookworm will be recruited and treated according to Good Clinical Practice recommendations.
Allergy will be excluded by skin prick tests. Amount and phenotype of Treg will be explored at several time points. Subsequent culture with environmental antigen will be performed on cryopreserved cells.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-65 years old adults in good health status
- •To live in rural regions at risk of soil transmitted helminthes
- •Hookworm infection (infected group)
- •Uninfected by Hookworms (control group)
排除标准
- •Pregnant woman
- •Positive allergic history
- •Auto-immune and/or HIV disease
- •Antihelminthics drug in the last 6 months and other current parasitic infection
研究组 & 干预措施
Hookworm infected
The amount, phenotype and function of Treg will be explored at several time points. Cultures with environmental antigen will be subsequently performed.
干预措施: Blood and feces sampling (Other)
Non infected (hookworms) healthy subjects
All the tests done in the experimental hookworm infected group will be also done in the comparator non infected group.
干预措施: Blood and feces sampling (Other)
结局指标
主要结局
Amount and phenotype of Treg
时间窗: 0-12 weeks
Four colors flow cytometry Treg measurements and phenotyping (FACSCantoII).
次要结局
未报告次要终点
研究者
Olivier Michel
Head of clinic
Brugmann University Hospital