Necrotizing Bacterial Dermohypodermitis-necrotizing Fasciitis (DHBN-FN) Mono- or Multi-microbial Streptococcus Beta-haemolytic: Study of Carriage in Patients and Their Entourage
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Rate of beta-hemolytic streptococcus in patients with DHBN-FN
研究概览
简要总结
The aim of the study is to evaluate streptococcal carriage by swab, pharyngeal, anal and perineal in patients with DHBN-FN, in the entourage living under the same roof as well as patients with erysipelas
The main hypothesis is the major role of chronic porting of patients and entourage in DHBN-FN to SBH.
Indeed, the chronic pharyngeal / anal / perineal carriage could be a gateway following a transient bacteremia for a DHBN-FN.
The transmission of germs from the surrounding to the patient plays a major role:
At the gateway level in the case of exogenous DHBN-FN At the origin of chronic carriage in the case of endogenous DHBN-FN Transmission of germs from the patient to the surrounding area also plays an important role in increasing the risk of invasive SBH infections in the surrounding area.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Major patient hospitalized for a DHBN-FN or erysipelas (clinical diagnosis determined at the entrance).
- •Signed informed consent.
- •Case contact
- •person of major age living under the same roof as a patient who has had a DHBN-FN.
- •Signed informed consent
排除标准
- •Minor patient
- •Immunosuppressed patient: active hematology, poorly controlled HIV, neutropenia (PNN <1000 / mm3).
- •Patient under guardianship or curatorship
- •Patient deprived of liberty by judicial or administrative decision
- •Patient not affiliated to a social security scheme and not a beneficiary of such a scheme
- •Case contact
- •Minor person
- •Person under tutorship or curatorship
- •Person deprived of liberty by judicial or administrative decision
- •Person not affiliated with a social security
结局指标
主要结局
Rate of beta-hemolytic streptococcus in patients with DHBN-FN
时间窗: Day 30
Evaluation of streptococcal carriage by swab, pharyngeal, anal and perineal in patients hospitalized for a DHBN-FN . Swabs made by the dermatologist. The detection of beta-hemolytic streptococcus will be made by culture
次要结局
- Prevalence of SBH carriage at the time of diagnosis(Day 0, Day 10)
- Sites of SBH carriage at the time of diagnosis(Day 0, Day 10)
- Rate of beta-hemolytic streptococcus in patients with erysipelas(Day 0)
- Rate of beta-hemolytic streptococcus in patients living under the same roof as patients with DHBN-FN(Up to 10 Days)
- Main factors of streptococcal virulence(Day 0, Day 10)