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临床试验/NCT05603780
NCT05603780已完成不适用

Cognitive, Emotional, Physiological, Chronobiological and Genetic Effects of a Time Underground Isolation

University Hospital, Caen1 个研究点 分布在 1 个国家目标入组 15 人开始时间: 2021年3月11日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
15
试验地点
1
主要终点
Physiology

研究概览

简要总结

The objectives of this scientific expedition are: a/ Evaluation of temporal cognitive perception and collective synchronization in a temporally anomalous universe (underground environment), b/ Influence of group living on the endogenous circadian rhythmicity of the central biological clock and peripheral clocks in a "free-running" situation (absence of light/natural darkness), c/Evaluation of cognitive and physiological performance in response to exposure to an extreme environment in a natural underground cavity (cave) without access to a time indicator for 40 days, d/Correlation of cognitive, behavioral, psychological, social, neurophysiological and physiological parameters, e/ Determination of adaptation or maladaptation criteria (biological, genetic, physiological, neurophysiological, psychological and cognitive) in an isolation environment (underground) f/ Study of the evolution of collective organization, decision making and leadership in an extreme isolation and management situation.

详细描述

This exceptional period has shown a significant desynchronization and loss of notion of time in a large number of people as well as important questions about human abilities to live in confined conditions. It is partly for this reason, but also to answer more fundamental questions on the perception of time that the extraordinary research expedition Deep Time was conceived: 40 days underground to know the links of our brain to time and synchronization within a group. A fundamental need for our future. This scientific expedition will take place entirely in France to ensure the feasibility and safety of the subjects and experimenters, under the direction of Christian Clot and the Institute of Human Adaptation, placed under the high patronage of the Ministry of Education, Research and Innovation.

The project addresses the fundamental question of human adaptation to the physical environment and the crucial role of the brain's neuroplasticity properties.

The present "Deep-Time" protocol naturally echoes the "out-of-time" isolation experiments conducted by the speleologist Michel Siffre starting in 1962 and its various components in the years that followed.

These "out of time" experiments led to certain conclusions. As curious as it may seem, in the absence of the time givers (synchronizers or Zeitgebers in German) that are the social rhythms and the day-night alternations, the spontaneous rhythm would settle on a rhythm of about 25 hours.

However, these experiments remained limited to isolated individuals, in conditions of spatial unity (no displacement outside of the work camps), leaving a whole field of research and questioning that the year 2021 has strongly emphasized.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
25 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Strictly right-handed Good health without any medical and psychiatric diseases No contraindications to MRI French or European nationality Not to be included in another biomedical protocol

排除标准

  • Being pregnant Minor, under guardianship or curatorship

结局指标

主要结局

Physiology

时间窗: every ten days up to 40 days

Physiological parameters (HRV, lean and fat mass by impedancemtry, weight in kg, core body temperature) in response to exposure to an extreme environment in a natural underground cave for 40 days.

Time

时间窗: every ten days up to 40 days

- Evaluation of time perception perceived by subjects (minute and days) every 10 days up to 40 days

chronobiology

时间窗: every 5 days up to 40 days

-Influence of group living on the endogenous circadian rhythmicity of the central biological clock and peripheral clocks in a "free-running" situation (absence of light / natural darkness): measurments of body core temperature, cortisol and melatonine salivary concentration circadian rythms

Cognition, Emotion and personnality

时间窗: every ten to 15 days up to 40 days

Evaluation of cognitive (taking decision, emotion, spatial cognition) through differents paradigms displayed on screen of Headset in 2D and 3D virtual reality. Mesurements of time reaction, risk score, number of strategy or procedural errors, time to achieve the tasks. Questionnaires (STAI, POMS, big five inventory, IP9)

Human Factors: ethological measurments with video 24/24, actimetric circadian rythms

时间窗: all along the cavern experiment for 40 days

- Evaluation of the capacity of a group to find a synchronicity and a way of life in a new context, extreme in its environmental and temporal dimensions and out of the initial competences of each group member. Measurments of social interaction, comparison of actimetric circadien rythm

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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