Correlation Between H.Pylori Colonization and Severity of Gastritis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 2
- 主要终点
- Correlation between H.pylori colonization and severity of gastritis.
研究概览
简要总结
To study the prevelance rate of H.pylori colonization in patients with gastritis.
To correlate the H.pylori colonization with endoscopic finding. To correlate both H.pylori colonization and endoscopic finding with clinical manifestation.
详细描述
Helicobacter pylori is a gram negative microaerophilic spiral bacterium that is usually found in the stomach and thereby cause infection , which is associated with varying degrees of damage of superficial and glandular epithelium.
Chronic gastritis is a histological entity that is defined by an inflammatory infiltrate of lymphoblasma cells, cocsometimes polynuclear neutrophils and by progressive glandular atrophy of the gastric mucosa,and probably the main cause of chronic inflammation in the gastric mucosa which is usually caused by H.pylori infection.
In addition to chronic gastritis almost all benign gastroduodenal diseases including peptic ulcer , mucosa associated lymphoid tissue lymphoma and malignant gastroduodenal adenocarcinoma occurs due to previous H.pylori infection that is usually started with gastric precancerous lesion, gastric atrophy , gastric intestinal metaplasia , dysplasia and then turned to gastric carcinoma.
So the evaluation of H.pylori infection status yo non-infection, past infection, current infection by endoscopy has therefore become increasingly important.
The Sydney grading system is one of the most important recognised tools yo charactize histological lesions of chronic gastritis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All patients with gastritis above 18 years old with chronic H.pylori infection documented by histological examination included in the study.
排除标准
- •All patients mentioned above who have previous gastrointestinal surgery and patients below 18y .
结局指标
主要结局
Correlation between H.pylori colonization and severity of gastritis.
时间窗: Baseline
Biopsy will be taken to correlate between severity of gastritis and colonization of H.pylori.
次要结局
未报告次要终点
研究者
Merna Mawgoud Zaki Bechit
Relation between H.pylori colonization and severity of gastritis
Assiut University