Comparison of Two Commercially Available Devices to Measure Nitric Oxide Lung Diffusing Capacity in Healthy, Non-smoking Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Difference in nitric oxide lung diffusing capacity (mL/min/mmHg)
研究概览
简要总结
The measurement of nitric oxide lung diffusing capacity (DLNO) has been recently standardised. To date, two pulmonary function devices are commercially available and are used for the measurement of DLNO. No previous study assessed differences in gas exchange outcomes (e.g., DLNO values) between both devices.
The aim of this project is to compare two commercially available devices that measure lung diffusing capacity for nitric oxide (DLNO).
- "MasterScreenTM" (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany
- "HypAir" ("HA", Medisoft, Dinant, Belgium).
详细描述
In a single-center, crossover study conducted at the University Hospital Zurich, Switzerland, 35 healthy, non-smoking adults (>=18 years) will be invited to perform DLNO measurements in random order using the MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium) devices during one study visit.
The order of the tests on the MasterscreenTM and HypAir devices will be randomly allocated using central randomisation.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 years and older
排除标准
- •Previous thoracic surgery
- •Chronic lung disease (e.g., asthma bronchiale, COPD)
- •Forced expiratory volume in 1s and/or forced vital capacity below the lower limit of normal based on spirometry [Quanjer et al. Eur Respir J 2005]
- •Current respiratory infection
结局指标
主要结局
Difference in nitric oxide lung diffusing capacity (mL/min/mmHg)
时间窗: 1 hour
Single-breath measurements with MasterScreenTM (PFT Pro, Jaeger, CareFusion, Hoechberg, Germany) and HypAir (Medisoft, Dinant, Belgium).
次要结局
- Difference in carbon monoxide lung diffusing capacity (mL/min/mmHg)(1 hour)
- Difference in inspiratory volume (L)(1 hour)
- Difference in expired concentrations for nitric oxide (in %)(1 hour)
- Difference in inspired concentrations for nitric oxide (in %)(1 hour)
- Difference in inspired concentrations for carbon monoxide (in %)(1 hour)
- Difference in expired concentrations for carbon monoxide (in %)(1 hour)
- Difference in inspired concentrations for oxygen (%)(1 hour)
- Difference in breath-hold time (s)(1 hour)
- Difference in expired concentrations for oxygen (%)(1 hour)
- Difference in Alveolar volume (L)(1 hour)
- Difference in inspired concentrations for helium (%)(1 hour)
- Difference in expired concentrations for helium (%)(1 day)