NCT00864773Unknown不适用
Intraocular Concentrations of Growth Factors and Cytokines in Chronic Central Serous Chorioretinopathy And the Effect of Therapy With Bevacizumab
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 10
- 主要终点
- Concentrations of growth factors and inflammatory cytokines in Aqueous humor
研究概览
简要总结
The pathophysiology of central serous chorioretinopathy remains controversial. traditional treatment is laser photocoagulation or photodynamic therapy.Recently Bevacizumab (Avastin, Genetech),an antibody to vascular endothelial growth factor (VEGF),has known antipermeability properties and therefore may theoretically reverse the changes seen in central serous chorioretinopathy. The aim of this study is To investigate concentrations of growth factors and inflammatory cytokines and to report the effect of therapy with bevacizumab in eyes with central serous chorioretinopathy
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with a diagnosis of central serous chorioretinopathy
- •Idiopathic neurosensory retinal elevation demonstrated by optical coherent tomography
- •Presence of focal leaks at the level of the RPE on fluorescein angiography
排除标准
- •Known side effects of systemic bevacizumab administration
- •Have a significant cardiovascular or thromboembolic history or were pregnant
结局指标
主要结局
Concentrations of growth factors and inflammatory cytokines in Aqueous humor
时间窗: at baseline
次要结局
- Central macular thickness at optical coherence tomography(baseline, 1 month, 3 months, 6 months)
研究者
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