Functional Magnetic Resonance Imaging of Formal Thought Disorders in Bipolar Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- CHU de Reims
- 入组人数
- 79
- 试验地点
- 2
- 主要终点
- brain activation profiles by Functional Magnetic Resonance Imaging
研究概览
简要总结
Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. The observations of the patient's speech and language behaviour due to flight of ideas or loss of goal probably result from an underlying disturbance in semantic networks dealing with semantic associations. The aim of our study will be to have a better comprehension of thought disorders in bipolar disorder by cognitive exploration of semantic processing.
详细描述
Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. During these episodes, formal thought disorders are observed, associated to emotional perturbation, behaviour troubles and some psychotic symptoms. During mania, the type of thought disorders observed are derailment, flight of ideas, with an increase in the amount of spontaneous speech and loss of goal. These observations of the patient's speech and language behaviour probably result from an underlying disturbance in semantic networks dealing with semantic associations. These networks have been studied extensively in schizophrenia but remain unknown in bipolar disorder. In this context, the aim of our study will be to have a better comprehension of formal thought disorders in bipolar disorder by cognitive exploration of semantic activation and inhibition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BD patients :
- •Men or women, right-handed
- •diagnosis of type 1 bipolar disorder, according to the DSM-IV criteria
- •aged from 18 to 65 years-old
- •Native French speaker
- •Affiliated to the social security
- •Healthy Controls (HC):
- •Men or women, right-handed
- •aged from 18 to 65 years-old
- •Native French speaker
- •Affiliated to the social security
排除标准
- •BD patients :
- •recent alcohol and/or drug abuse or dependence
- •significant general medical illness, including neurological disorders or head trauma
- •sensorial impairment (visual and/or hearing)
- •Contraindication to the use of MRI
- •first-degree-relative history of bipolar disorder, schizophrenia or schizoaffective disorder according to DSM-IV
- •recent alcohol and/or drug abuse or dependence
- •significant general medical illness, including neurological disorders or head trauma
- •sensorial impairment (visual and/or hearing)
- •Contraindication to the use of MRI
结局指标
主要结局
brain activation profiles by Functional Magnetic Resonance Imaging
时间窗: inclusion visit
次要结局
未报告次要终点