Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 97
- 主要终点
- Comparison of serum fetuin A levels between patients with Hashimoto thyroiditis and healthy subjects
研究概览
简要总结
Fetuin-A levels are reported to be low as a negative acute phase reactant in systemical inflammatory situations. Hashimoto thyroiditis is characterized with inflammation. In this study, we hypothesised that the serum fetuin A levels could be found to be low due to inflammation in patients with Hashimoto thyroiditis
详细描述
Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the eligibility criteria will be included in the study. Approval of the local ethics committee and informed consent of the participants will be received for the study. The study is conducted in accordance with the Declaration of Helsinki. Demographic characteristics, concomitant diseases, smoking and alcohol drinking habits, concomitant medication usage, anthropometric and biochemistry data of the eligible patients will be recorded. Patient group will consist of patients with newly diagnosed Hashimoto thyroiditis and the control group will consist of healthy volunteers.
Groups will be compared according to their demographic, an¬thropometric and biochemistry data and serum fetuin-A levels. In order to detect the relationship between the serum fetuin-A levels and clinical features, correlation analyses will be done.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients newly diagnosed with Hashimoto thyroiditis
排除标准
- •Acute infection
- •Acute or chronic inflammatory disease
- •Anti-inflammatory treatment (non-steroidal anti-inflammatory, corticosteroids etc.)
- •Hypoxic situations (chronic obstructive pulmonary disease etc.)
- •Severe heart, kidney and liver disease
- •Pregnancy
- •Endocrine disorders
- •Malignancy
- •Usage of drug that affects thyroid hormone levels
结局指标
主要结局
Comparison of serum fetuin A levels between patients with Hashimoto thyroiditis and healthy subjects
时间窗: 1 day (The blood samples were obtained on the same day participants arrived to outpatient clinics.)
次要结局
未报告次要终点
研究者
Sevilay Muratli
M.D.
Istanbul Medeniyet University
