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临床试验/NCT01884649
NCT01884649已完成不适用

Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis

Istanbul Medeniyet University0 个研究点目标入组 97 人开始时间: 2012年5月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
97
主要终点
Comparison of serum fetuin A levels between patients with Hashimoto thyroiditis and healthy subjects

研究概览

简要总结

Fetuin-A levels are reported to be low as a negative acute phase reactant in systemical inflammatory situations. Hashimoto thyroiditis is characterized with inflammation. In this study, we hypothesised that the serum fetuin A levels could be found to be low due to inflammation in patients with Hashimoto thyroiditis

详细描述

Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the eligibility criteria will be included in the study. Approval of the local ethics committee and informed consent of the participants will be received for the study. The study is conducted in accordance with the Declaration of Helsinki. Demographic characteristics, concomitant diseases, smoking and alcohol drinking habits, concomitant medication usage, anthropometric and biochemistry data of the eligible patients will be recorded. Patient group will consist of patients with newly diagnosed Hashimoto thyroiditis and the control group will consist of healthy volunteers.

Groups will be compared according to their demographic, an¬thropometric and biochemistry data and serum fetuin-A levels. In order to detect the relationship between the serum fetuin-A levels and clinical features, correlation analyses will be done.

研究设计

研究类型
Observational
时间视角
Cross Sectional

入排标准

年龄范围
20 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • patients newly diagnosed with Hashimoto thyroiditis

排除标准

  • Acute infection
  • Acute or chronic inflammatory disease
  • Anti-inflammatory treatment (non-steroidal anti-inflammatory, corticosteroids etc.)
  • Hypoxic situations (chronic obstructive pulmonary disease etc.)
  • Severe heart, kidney and liver disease
  • Pregnancy
  • Endocrine disorders
  • Malignancy
  • Usage of drug that affects thyroid hormone levels

结局指标

主要结局

Comparison of serum fetuin A levels between patients with Hashimoto thyroiditis and healthy subjects

时间窗: 1 day (The blood samples were obtained on the same day participants arrived to outpatient clinics.)

次要结局

未报告次要终点

研究者

发起方
Istanbul Medeniyet University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Sevilay Muratli

M.D.

Istanbul Medeniyet University

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