Serum Prostatic Specific Antigen (PSA) Changes After Bipolar and Monopolar Transurethral Resection of the Benign Prostatic Hyperplasia, a Randomized Controlled Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 2
- 主要终点
- serum PSA changes after bipolar and monopolar transurethral resection of the benign prostatic hyperplasia
研究概览
简要总结
To use PSA levels after bipolar and monopolar transurethral resection of the benign prostatic hyperplasia as an indicator of the quality of resection .
详细描述
PSA is a protein produced from the prostate epithelium and secreted in semen in huge amounts , small amount find its way to the circulation ,its function is to allow mobility of the sperms by interacting with the Semenogelin . clinical BPH can be defined as prostate adenoma/adenomata, causing a varying degree of BOO, which may eventually cause harm to the patients ,Treatment of this condition varies from conservative, medical and surgical depending on factors related to the patient and the surgeon preference . The early reports of minimally invasive treatment of the prostate dated back to 1937, since then and remarkable development is noticed . TURP is the golden treatment in the BPH . Studies compare between the methods according the blood transfusion , operation time retention after catheter removal , urethral complications , TUR syndrome and hospital-stay which show that bipolar is better. To our knowledge after few studies compare between the techniques according PSA also these studies show weakness in their statistically analysis with no difference between the methods .investigators aim is to study the effect of the operations on PSA levels as an indicator of the quality of resection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 50 Years 至 80 Years(Adult, Older Adult)
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Patients agreeing to participate, clinically fit, age from 50 to 80 years with LUTS related to benign prostate enlargement with no neurological disorder
排除标准
- •Prostate cancer
- •Previous urethral or prostate surgery
- •Neurogenic bladder
- •Urethral stricture
- •Patient unfit for surgery
研究组 & 干预措施
Bipolar TURP
Patients thats will undergo bipolar TURP
干预措施: TURP (Procedure)
Monopolar TURP
Patients thats will undergo monopolar TURP
干预措施: TURP (Procedure)
结局指标
主要结局
serum PSA changes after bipolar and monopolar transurethral resection of the benign prostatic hyperplasia
时间窗: within one month after intervention
To use PSA levels changes after both techniques (bipolar and monopolar transurethral resection of the benign prostatic hyperplasia)as an indicator of the quality of resection
次要结局
- International Prostate Symptom Score(within one month after intervention)
研究者
Andrew Hamam Wahba Gerges
Principal Investigator
Assiut University
