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临床试验/NCT05533047
NCT05533047Unknown不适用

Serum Prostatic Specific Antigen (PSA) Changes After Bipolar and Monopolar Transurethral Resection of the Benign Prostatic Hyperplasia, a Randomized Controlled Study.

Assiut University0 个研究点目标入组 2 人开始时间: 2022年10月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
入组人数
2
主要终点
serum PSA changes after bipolar and monopolar transurethral resection of the benign prostatic hyperplasia

研究概览

简要总结

To use PSA levels after bipolar and monopolar transurethral resection of the benign prostatic hyperplasia as an indicator of the quality of resection .

详细描述

PSA is a protein produced from the prostate epithelium and secreted in semen in huge amounts , small amount find its way to the circulation ,its function is to allow mobility of the sperms by interacting with the Semenogelin . clinical BPH can be defined as prostate adenoma/adenomata, causing a varying degree of BOO, which may eventually cause harm to the patients ,Treatment of this condition varies from conservative, medical and surgical depending on factors related to the patient and the surgeon preference . The early reports of minimally invasive treatment of the prostate dated back to 1937, since then and remarkable development is noticed . TURP is the golden treatment in the BPH . Studies compare between the methods according the blood transfusion , operation time retention after catheter removal , urethral complications , TUR syndrome and hospital-stay which show that bipolar is better. To our knowledge after few studies compare between the techniques according PSA also these studies show weakness in their statistically analysis with no difference between the methods .investigators aim is to study the effect of the operations on PSA levels as an indicator of the quality of resection.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Other
盲法
Single (Participant)

入排标准

年龄范围
50 Years 至 80 Years(Adult, Older Adult)
性别
Male
接受健康志愿者
否

入选标准

  • •Patients agreeing to participate, clinically fit, age from 50 to 80 years with LUTS related to benign prostate enlargement with no neurological disorder

排除标准

  • •Prostate cancer
  • •Previous urethral or prostate surgery
  • •Neurogenic bladder
  • •Urethral stricture
  • •Patient unfit for surgery

研究组 & 干预措施

Bipolar TURP

Active Comparator

Patients thats will undergo bipolar TURP

干预措施: TURP (Procedure)

Monopolar TURP

Active Comparator

Patients thats will undergo monopolar TURP

干预措施: TURP (Procedure)

结局指标

主要结局

serum PSA changes after bipolar and monopolar transurethral resection of the benign prostatic hyperplasia

时间窗: within one month after intervention

To use PSA levels changes after both techniques (bipolar and monopolar transurethral resection of the benign prostatic hyperplasia)as an indicator of the quality of resection

次要结局

  • International Prostate Symptom Score(within one month after intervention)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Andrew Hamam Wahba Gerges

Principal Investigator

Assiut University

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