Oocyte Survival After Vitrification in an Open or Closed Commercial Device: Study on Sibling Donor Oocytes.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Survival rate
研究概览
简要总结
The survival rate (and embryo quality) of donor oocytes with two commercially available devices.
详细描述
Donor sibling oocytes will be vitrified with two commercially available devices. The first device is closed vitrification with closed storage and the second device is open vitrification with closed storage. Oocyte acceptors receive oocytes from both devices. With the increase in cooling rate generated by the open vitrification (second device), we expect to get an increase in survival rate of 10%. Besides this, embryo quality will be assessed with oocytes obtained from both devices.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 36 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Donor: ≤36 years old on day of oocyte retrieval
- •Donor: ≥ 6 mature oocytes
排除标准
- •Donor: < 6 mature oocytes
研究组 & 干预措施
closed vitrification with closed storage
Half of the oocytes of every donor will be vitrified with the Cryo Bio Systems High Security vitrification (CBSvit HS) device; the standard device in our lab.
干预措施: CBSvit HS device (Device)
open vitrification with closed storage
Half of the oocytes of every donor will be vitrified with the Cryotop closed system (Cryotop SC).
干预措施: Cryotop SC device (Device)
结局指标
主要结局
Survival rate
时间窗: up to 6 days after every warming cycle
The purpose is to assess the survival rate of donor oocytes with the two vitrification devices.
次要结局
- Embryo development(up to 6 days after every warming cycle)
研究者
Neelke De Munck
MSc.
Universitair Ziekenhuis Brussel