Short Versus Long Duration of Therapy for Streptococcus Pneumoniae Bloodstream
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Recurrence
研究概览
简要总结
Streptococcus pneumoniae is a gram-positive (GP) bacteria responsible for common infections such as community-acquired pneumonia (CAP), as well as complicated infections such as bacteremia, infective endocarditis and meningitis. S. pneumoniae bacteremia ranks among the top 10 most common pathogens associated with bloodstream infections and correlates with high morbidity and mortality worldwide.
详细描述
The Infectious Diseases Society of America (IDSA) guidelines for CAP management advocate for short courses of antibiotics for CAP treatment. However, it does not address duration of therapy for common CAP pathogens such as S. pneumoniae when associated with blood stream infections (BSI). 3
Currently, GP bacteremia duration of therapy typically ranges from 7 to 14 days based on IDSA guideline recommendations for Staphylococcus aureus bacteremia with no further definitive consensus.4 Additionally, lack of data and randomized clinical trials on the efficacy and safety of short compared to long treatment duration have led to variability in practice. Most randomized clinical trials as well as retrospective studies on treatment duration, have been conducted mainly in gram-negative BSI
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• ≥18 years of age
- •S. pneumoniae isolated from ≥1 blood cultures
- •Active IV antibiotic therapy within 48 hours of the first positive blood culture(7,8)
- •Clinical stability by day 10 of therapy
排除标准
- •• Treatment duration <5 days or >16 days
- •Death before completion of therapy (<10 days vs. ≥ 10 days )
- •Polymicrobial BSI
- •Invasive infection caused by S. pneumoniae (endocarditis, meningitis, and lung abscess)
结局指标
主要结局
Recurrence
时间窗: 30 days
Reinfection with streptococcal pneumonia, within 30 days of antibiotic completion
All-cause mortality
时间窗: 30 days
Death within 30 days of antibiotic completion
Infection related-hospitalization
时间窗: 30 days
hospital readmission with streptococcal pneumonia, bacteremia, endocarditis, meningitis, and lung abscess within 30 days of antibiotic completion
次要结局
- Central venous catheter placement(30 days)
- ICU Length of stay(LOS)(30 days)
- Hospital LOS(30 days)
- Occurrence of C. difficile infection(30 days)
- Total antibiotic treatment duration(30 days)