Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Maximal Fat Oxidation
研究概览
简要总结
The purpose of this research study is to determine if the cold-induced change in fat burning during exercise is different between females and males.
详细描述
It is well characterized that females rely more on fat oxidation compared to men during standardized exercise. Exposure to cold during exercise increases fat oxidation in humans. It has been shown that the biological sex differences in substrate oxidation observed during exercise persist in the cold. However, it is unclear if the degree of the effect of cold on substrate oxidation during exercise is different between females and males.
The purpose of this study is to determine if the change in maximal fat oxidation that occurs in cold compared to room temperature environments is different between females and males.
The hypotheses are 1) females will have greater maximal fat oxidation than males in both conditions, and 2) the change in maximal fat oxidation between the control and cold conditions will be the same in females and males.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-40 years (inclusive)
- •Weight stable (no change in body mass greater than 5 lbs. within the previous 6 months.
- •Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits
- •Competency in English as informally assessed by comprehension of the Informed Consent. This study involves maximal exercise testing; for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.
- •Regular exercise (i.e., at least 150 minutes of moderate-vigorous exercise per week)
排除标准
- •Use of hormonal contraceptives
- •History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
- •Pregnancy or breast feeding
- •Habitual use of tobacco/nicotine products or recreational drugs (2 or more uses within the previous month)
研究组 & 干预措施
Exercise at room temperature
Study participants will ride an exercise bike
干预措施: Room Temperature (Other)
Exercise at cold temperature
Study participants will ride an exercise bike. Room temperature will be 5 ºC
干预措施: Cold temperature (Other)
结局指标
主要结局
Maximal Fat Oxidation
时间窗: During exercise while in the lab
Using indirect calorimetry, fat oxidation will be determined. The maximal value for fat oxidation will be recorded.
次要结局
未报告次要终点