Evaluation of the Prevalence and Antibiotic Susceptibility Pattern of Multidrug Resistance Bacteria and Its Association With Patients' Predictive Factors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Prevalence of multidrug resistance bacteria in isolated patient specimen
研究概览
简要总结
- To determine the prevalence of multidrug resistance bacteria in patient with different infections
- To evaluate patients' predictive risk factors of antimicrobial resistance
- To assess the association between patients' factors and prevalence of MDR bacteria
详细描述
Antimicrobial resistance is one of the most critical public health issue in this century . WHO declared antimicrobial resistance as one of the top ten global health threats that impend the effective management and prevention of evolving infections .
Antimicrobial resistance nowadays poses a big challenge because of the emerging of resistance to the antibiotics that previously effective and development of multidrug resistance infections with subsequent increase in morbidity, mortality and financial loss .
In spite of WHO health strategies that taken to face multidrug resistance problem, the burden of antimicrobial resistance in Europe is compared with combined burden of influenza and HIVS .while in USA the estimated antibiotics resistance infections is 2.8 millions and the related deaths exceeded 35,000 every year and expected to reach to ten million deaths with collective cost of 100 trillion USD annually in 2050 .
Numerous studies reported that self-medications, improper prescription, overuse of antibiotics, deficiency of antibiotics susceptibility test and limited knowledge and attitude of population towards antibiotics are the main factors that lead to antibiotics efficacy being reduced with long hospital stay. Other studies stated that the predictive indicators of MDR tragedy are age, gender, comorbidities, previous hospital stay or antibiotic use .
In low and middle income countries like IRAQ there is a difficulty in estimation the scope of antibiotics resistance problem and its evolving over time due to the lack of surveillance, besides alarmingly excessive antibiotics consumption added other challenges and urged us to aim this study .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who were screened for MDR bacteria
- •patients who accepted to participate in the study
排除标准
- •patients with no growth media
- •patients who cannot communicated
结局指标
主要结局
Prevalence of multidrug resistance bacteria in isolated patient specimen
时间窗: based line value (zero months)
proportion of MDR bacteria that detected in isolated specimen
Association of patient's factors with prevalence of multidrug resistance Bacteria.
时间窗: based line value (zero months)
exploring the association between patient's factors and the prevalence of MDR bacteria by multivariate analysis
次要结局
- Prevalence of extended spectrum β lactamase producers (ESBL)(based line value (zero months))
- Prevalence of Methicillin resistance staph. Aureus (MERSA)(based line value (zero months))
- Knowledge, attitude and practice (KAP) toward antibiotic use(based line value (zero months))
- Prevalence of vancomycin (-resistant Enterococci VRE)(based line value (zero months))
- Risk factors for antibiotic resistance(based line value (zero months))
研究者
Zahraa Najah Mohsin
general pharmacist
Kufa University
