Pronostic Value of Type I ANTi-Interferon Antibodies in Patients With COVID-19 Acute Respiratory Failure: a Multicenter Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,022
- 试验地点
- 1
- 主要终点
- day-28 mortality
研究概览
简要总结
Severe SARS-CoV-2 infections are frequently associated with the acute respiratory distress syndrome (ARDS), which leads to a mortality of 30-40%. An altered type I interferon (IFN) response has been demonstrated in patients with severe COVID-19, together with a high viral load.
The aim of the current work is, in a large cohort of patients with severe COVID-19 admitted in the ICU, to determine the prevalence of patients with positive anti-IFN antibodies and to determine their outcome, as compared to patients having negative anti-IFN antibodies.
详细描述
Severe SARS-CoV-2 infections are frequently associated with the acute respiratory distress syndrome (ARDS), which leads to a mortality of 30-40%. An altered type I interferon (IFN) response has been demonstrated in patients with severe COVID-19, together with a high viral load. A recent study revealed that 10% of patients admitted in the intensive care unit (ICU) for severe COVID-19 had positive type I anti-IFN antibodies. Such finding has potentially important therapeutic implications, as patients having positive anti-IFN antibodies could benefit from targeted interventions, including plasmapheresis. The aim of the current work is, in a large cohort of patients with severe COVID-19 admitted in the ICU, to determine the prevalence of patients with positive anti-IFN antibodies and to determine their outcome, as compared to patients having negative anti-IFN antibodies.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •SARS-CoV-2 infection with a positive PCR
- •Patient admitted in the ICU for acute respiratory failure (SpO2≤90% and need for supplemental oxygen or any kind of ventilator support)
- •Patient or next of keen was informed of study inclusion
排除标准
- •Patient with SARS-CoV-infection but no acute respiratory failure
结局指标
主要结局
day-28 mortality
时间窗: at day-28 of intensive care unit (ICU) admission
comparaison of day-28 mortality in patients having positive versus negative type I anti-IFN antibodies
次要结局
- rate of positivity of type I anti-IFN antibodies(3 months of ICU admission)
- Factors associated with type I anti-IFN antibody positivity(24 hours of ICU admission)
- hospital mortality(at day 90.)