A Pilot Study to Assess the Feasibility of Detection and Quantification of Differences in Hodgkin Lymphoma and Diffuse Large B-cell Lymphoma Using FDG-PET/CT Imaging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Percentage Change in Maximum Lesional FDG Uptake From 60 to 180 Minutes After FDG Administration
研究概览
简要总结
RATIONALE: Imaging procedures, such as positron emission tomography or computed tomography, may help in detecting differences between Hodgkin lymphoma or diffuse large B-cell lymphoma cancer cells. PURPOSE: This clinical trial is studying positron emission tomogaphy and computed tomography in determining differences in Hodgkin lymphoma and diffuse large B-cell lymphoma.
详细描述
OBJECTIVES:
I. Assess the feasibility of detection and quantification of differences in the temporal and spatial distribution of FDG uptake between lesions of HL and DLBCL.
OUTLINE:
Patients undergo fludeoxyglucose F18 (FDG) positron emission tomography/computed tomography scans 60 and 180 minutes after FDG administration.
After completion of study, patients are followed for 24 hours.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects with a pathologically-proven diagnosis of classic HL or DLBCL with measurable disease by any imaging technique or physical examination.
排除标准
- •Pregnant or nursing,
- •Uncontrolled diabetes mellitus,
- •Active infection,
- •Inability to give informed consent or to comply with all study procedures,
- •Subjects may be excluded at the discretion of the principal investigator or study team members.
研究组 & 干预措施
Fludeoxyglucose F18 (FDG) PET/CT scans
Patients undergo fludeoxyglucose F18 (FDG) positron emission tomography/computed tomography scans and 180 minutes after FDG administration.
干预措施: Computed Tomography (Procedure)
Fludeoxyglucose F18 (FDG) PET/CT scans
Patients undergo fludeoxyglucose F18 (FDG) positron emission tomography/computed tomography scans and 180 minutes after FDG administration.
干预措施: Positron emission tomography (Procedure)
Fludeoxyglucose F18 (FDG) PET/CT scans
Patients undergo fludeoxyglucose F18 (FDG) positron emission tomography/computed tomography scans and 180 minutes after FDG administration.
干预措施: Fludeoxyglucose F18 (Radiation)
结局指标
主要结局
Percentage Change in Maximum Lesional FDG Uptake From 60 to 180 Minutes After FDG Administration
时间窗: 2 hours (between 60 minutes post-administration and 180 minutes post-administration)
Lesional fluorodeoxyglucose (FDG) uptake is measured by standardized uptake value (SUV). The study compared the percentage of change in maximum SUV over 2 hours (first measure was 60 minutes post-administration and second timepoint was 180 minutes post-administration).
次要结局
未报告次要终点