Vitamins, Breastmilk HIV Shedding, and Child Health
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 771
- 试验地点
- 1
- 主要终点
- cell-free viral load and/or cell-associated proviral load in breast milk
研究概览
简要总结
The purpose of this study is to analyze stored samples and data collected during the conduct of the study "A Trial of Vitamins in HIV Progression and Transmission" (HD32257). The aims are to examine the effect of vitamin supplementation on HIV infected women during pregnancy on a number of parameters in breastmilk.
详细描述
The purpose of this study is to analyze stored samples and data collected during the conduct of the study "A Trial of Vitamins in HIV Progression and Transmission" (HD32257). The aims are to examine the effect of vitamin supplementation on HIV infected women during pregnancy
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
cell-free viral load and/or cell-associated proviral load in breast milk
时间窗: Delivery, 3 months, and 6 months after delivery
concentration of vitamins A, B12, and E in breast milk
时间窗: Delivery, 3 months, and 6 months post-delivery
subclinical mastitis
时间窗: Delivery, 3 months, and 6 months after delivery
次要结局
- infant mortality and morbidity from diarrhea(Delivery, 3 months and 6 months after delivery)
- post-natal mother-to-child transmission of HIV(Delivery, 3 months, and 6 months post-delivery)
- a.) CCR5 expression in differentiating monocytes and differentiated monocyte-derived macrophages(N/A (in vitro experiment))
- HIV-1 replication in differentiating monocytes acutely infected with a subtype C HIV-1 clone, differentiated non-dividing MDMs acutely infected with the HIV-1 MJ4 clone, and differentiated non-dividing MDMs chronically infected with the HIV-1 MJ4 clone.(N/A (in vitro experiment))