ISRCTN32422978已完成不适用
GEO 002: Is a reduction in urate levels the mechanism by which allopurinol improves endothelial function?
niversity of Dundee (UK)0 个研究点目标入组 30 人开始时间: 2006年1月27日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Three-month period free of hospitalisations prior to screening
- •2. Ability to give written informed consent to participate in the study
- •3. Diagnosis of mild to moderate chronic heart failure
排除标准
- •1. History of drug sensitivity or allergy to probenecid or vitamin C
- •2. Current treatment with probenecid, allopurinol, theophylline, warfarin or cytotoxic drugs (including azothiaprine or mercaptopurine)
- •3. History of acute gout or porphyria
- •4. Evidence of significant disease that could impair absorption, metabolism or excretion of orally-administered medication i.e.
- •a. Renal disease (serum creatinine 180 umol/l)
- •b. Clinically significant hepatic disease (either by lab work, i.e. alanine aminotranferease (ALT) and aspartate aminotransferase (AST) (ALT/AST > 3 times upper limit of normal, or by clinical assessment)
- •5. Any condition with sufficient severity to impair co-operation in the study
- •6. History of chronic alcoholism / intravenous drug abuse
- •7. Use of another investigational drug within three months of entry into the study or within five half-lives of the investigational drug (the longer time period applying)
- •8. Pregnancy, breast feeding or being of childbearing age and not taking oral contraceptives, all pre-menopausal women will be required to undergo a pregnancy test
- •9. Patients on aspirin doses greater than 150 mg/day
研究者
相似试验
已完成
不适用
Analyzing the effect of serum uric acid reduction using Allopurinol on vitamin D levels in hemodialysis patientsHemodialysis patients.Extracorporeal dialysisDialysis (renal) NOSIRCT2015041721803N1Vice chancellor for research center of Shahrekord University of Medical Sciences92
已完成
3 期
Study about effect of agressive uric acid decrease treatment on left ventricular hypertrophyeftVentricular HypertrophyJPRN-UMIN000014113Research office of Study of effect of UA decrease treatment on LVH240
已完成
不适用
An investigation of the serum uric acid-lowering effects of febuxostat in gout/hyperuricemia patients according to disease typeHyperuricemia and goutJPRN-UMIN000007362Clinical research consortium on uric acid100
已完成
不适用
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia in chronic kidney disease.Hyperuricemic patients with CKDJPRN-UMIN000005573Yokohama City University Medical Center40
进行中（未招募）
1 期
The effect of intensive urate lowering therapy (ULT) with febuxostat in comparison with allopurinol on cardiovascular risk in patients with gout (short title: the FORWARD trial)goutMedDRA version: 20.0Level: PTClassification code 10018627Term: GoutSystem Organ Class: 10027433 - Metabolism and nutrition disordersEUCTR2014-005567-33-ITA. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L.182