Goal Direct Therapy to Prevent Acute Kidney Injury After Cardiac Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 214
- 主要终点
- Acute Kidney Injury
研究概览
简要总结
This is an randomised controlled trial to investigate an strategy based in a protocol in prevention of acute kidney injury after cardiac surgery.
详细描述
This is a prospective, randomized controlled trial to assess the influence of use of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in the development of the Acute Kidney Injury in the postoperative period of cardiac surgery. Patients undergoing cardiac surgery at the Heart Institute (InCor) - Brazil, will be randomized and in accordance with a list of random numbers, generated by a computer program, will be allocated in one of the groups (GDT or standard).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cardiac surgery with Cardiopulmonary Bypass (CPB); Age greater than 18 years; Chronic kidney disease stages 3 and 4 (GFR less than 60 mL/min and greater than 15 mL/min); Sign the informed consent form.
排除标准
- •Chronic renal insufficiency (GFR less than 15 mL/min); Heart surgery without CPB; Aortic procedures; Heart transplant or congenital heart disease; Prior use of Intra-Aortic Balloon Pump; Decompensated heart failure; Participation in other research protocol.
结局指标
主要结局
Acute Kidney Injury
时间窗: Within 48h after cardiac surgery
Development of acute kidney injury according to AKIN (Acute Kidney Injury Network) criterion.
次要结局
- Serious clinical complications(For 28 days)
研究者
Eduesley Santana Santos
RN, Ph.D
University of Sao Paulo