Effect of Cinnamon on Gastric Emptying, Arterial Stiffness, Postprandial Lipaemia, Glycaemia, and Appetite Responses to High-fat Breakfast
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- The effect of 3grams cinnamon on gastric emptying half time
研究概览
简要总结
The purpose of this study is to determine whether 3 g cinnamon was sufficient to delay the gastric emptying rate of a high-fat solid meal and subsequently reduce postprandial blood glucose and lipid responses, oxidative stress, arterial stiffness and satiety responses in a healthy adult population.
详细描述
Cinnamon has been shown to delay gastric emptying (GE) of a high-carbohydrate meal and reduce postprandial glycaemia in healthy adults. However, it is dietary fat which is implicated in the etiology and is associated with obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD). We aimed to determine the effect of 3 g cinnamon on GE, postprandial lipemic and glycemic responses, oxidative stress, arterial stiffness, as well as appetite sensations and subsequent food intake following a high-fat (HF) meal.
The effect of acute oral administration of 3 g cinnamon on gastric emptying of a high-fat pancake test meal and subjective appetite sensations by visual analogue scale will be measured for six hours postprandially. During this time course, measurements of postprandial lipemic, glycemic, oxidative stress and arterial stiffness responses will be collected. Subsequently, food intake will be measured using an ad libitum buffet meal. The study will be conducted in a randomized, placebo-controlled, single-blinded manner in 9 healthy subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults aged 18-35 years
- •Recreationally trained individuals (participate in at least 2hrs/wk of individual/team sport)
- •Not currently taking antioxidant or lipid-lowering medication
- •Fasting blood lipid, glucose and blood pressure (BP) levels were all within the normal limits.
排除标准
- •History of gastrointestinal-related conditions, diabetes mellitus or cardiovascular disease.
- •Allergies to foods in study.
- •Blood disorder
- •Pregnancy.
结局指标
主要结局
The effect of 3grams cinnamon on gastric emptying half time
时间窗: During the 6.5 hours post ingestion
次要结局
- Oxidative stress(During the 6.5 hours after ingestion)
- Arterial stiffness(During the 6.5 hours after ingestion)
- Lipaemia(During the 6.5 hours after ingestion)
- Glycemia(During the 6.5 hours after ingestion)
- Appetite(During the 6.5 hours after ingestion)
- Food intake(6 hours post-prandially)