Acute Beetroot Juice Supplementation and Peripheral Chemoreflex Sensitivity in Patients With Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Changes in peripheral chemoreflex sensitivity
研究概览
简要总结
The main purpose of this study is to determine if acute beetroot juice supplementation reduces peripheral chemoreflex sensitivity in patients with obstructive sleep apnea. All subjects will consume low-dose (BRL), higher-dose (BRH), and placebo (BRP) beetroot juice randomly on three independent study visits. Beetroot juice also improves blood flow thus, the investigators will also measure blood flow to the carotid chemoreceptors.
详细描述
Four-weeks of daily beetroot juice supplementation reduces peripheral chemoreflex sensitivity in healthy older adults who have 'normal' responses to acute hypoxia. Patients with obstructive sleep apnea have exaggerated peripheral chemoreflex sensitivity. It remains unknown if beetroot juice supplementation reduces peripheral chemoreflex sensitivity in patients with obstructive sleep apnea. Additionally, increasing blood flow to the peripheral chemoreceptors reduces sensitivity. Given that beetroot juice improves blood flow, the investigators will also measure common carotid artery blood flow at rest and during hypoxia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •OSA group: patients recently diagnosed with mild-to-moderate OSA
- •Control group: healthy individuals
排除标准
- •Diagnosis of heart disease
- •Diagnosis of diabetes
- •Diagnosis of any autonomic disorders
- •Diagnosis of kidney disease
- •Diagnosis of central sleep apnea
- •Regular physical activity exceeding 30 minutes 3 days/week
- •A body mass index ≥40 kg/m2
- •Current or former use of a continuous positive airway pressure machine
- •Current tobacco use
- •Currently prescribed hormone replacement therapy
结局指标
主要结局
Changes in peripheral chemoreflex sensitivity
时间窗: Before and after consuming all supplements (within three hours)
The ventilatory response to acute hypoxia will be measured via pneumotachometer.
次要结局
- Changes in common carotid artery blood flow(Before and after consuming all supplements (within three hours))
研究者
Darren P Casey
Assistant Professor
University of Iowa