An Evaluation of Vasopressor Requirement, Hemodynamic Response and Measures of Tissue Perfusion With the Administration of Drotrecogin Alfa (Activated) as Part of Physician-Directed Therapy in Patients With Septic Shock

简要总结

主要结局

次要结局

• Lactate Level(Baseline to 6 Hours)
• Cardiovascular Performance Measures Obtained With a Pulmonary Artery Catheter - Cardiac Index(Baseline to 24 Hours)
• Change From Baseline to 96 Hour Endpoint in Cumulative Vasopressor Index (CVI)(Baseline, 96 hours)
• Mean Arterial Pressure(baseline to 24 hours)
• Microcirculatory Measures From Sidestream Darkfield (SDF) Microscopy - Small Vessel Microvascular Flow Index (MFI)(Baseline to 24 Hours)
• Sequential Organ Failure Assessment (SOFA) Score at Baseline and 24 Hours(Baseline and 24 Hours)
• Change From Baseline in Creatinine Clearance (CrCl) at 24 Hours(Baseline and 24 hours)
• 7 Day All-cause In-hospital Mortality(baseline to 7 days)
• Endogenous Protein C Level(Baseline to 24 Hours)
• Mixed Venous Oxygen Saturation(Baseline to 24 Hours)