NL-OMON43743招募中不适用
Female subfertility: a first sign of metabolic and cardiovascular anomalies? - Female subfertility: a metabolic and vascular profile
Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 516 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 516
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Study 1*The metabolic syndrome and female subfertility* :
- •Study group:
- •- primary subfertility, defined as having no previous pregnancy, or secondary subfertility, defined as a fertility problem after an ongoing pregnancy
- •- age 18 * 41 years
- •Control group:
- •- women with an uneventful pregnancy in history
- •- at least 6 months post partum
- •- age 18 * 41 years;Study 2 *The cardiovascular profile in female subfertility*:
- •Study groups:
- •- primary subfertility, defined as having no previous pregnancy, or secondary subfertility, defined as a fertility problem after an ongoing pregnancy
- •- age 18 * 41 years
- •- participation in study 1
- •- no abnormalities in the basic fertility work up (*unexplained subfertility*); studygroup 1, or *expected* decreased ovarian reserve (Follicle Stimulating Hormone (FSH) > 8 u/l); studygroup 2
- •Control group:
- •- women with an uneventful pregnancy in history
- •- at least 6 months post partum
- •- age 18 * 41 years;Study 3 *The cardiovascular profile in women with a poor ovarian response* :
- •Study group:
- •- primary or secondary subfertility
- •- age 18 * 40 years
- •- IVF / ICSI treatment in the period from 2010 - 2013
- •- proven decreased ovarian response (* 3 oocytes at an ovum-pick up)
- •- maximal stimulation dosage of 250 IU FSH per day
- •Control group:
- •- primary or secondary subfertility
- •- age 18 * 40 years
- •- IVF / ICSI treatment in the period from 2010 - 2013
- •- severe male factor (TMC < 3 million spermatozoa)
- •- retrieved * 4 oocytes at an ovum-pick up
- •- normal stimulation dosage of 150 IU FSH per day
排除标准
- •Study 1 *The metabolic syndrome and female subfertility*
- •There are no exclusion criteria for the study of the metabolic syndrome in the subfertile women.
- •For the control group exclusion criteria are:
- •- current pregnancy
- •- hormonal medication
- •- breastfeeding;Study 2 *The cardiovascular profile in female subfertility*
- •For the studies of the measurement of the uterine artery PI, plasma volume, intima media thickness and endothelial function exclusion criteria in all women are:
- •- hypertension, defined as a blood pressure exceeding 140 mm Hg systolic or 90 mm Hg diastolic, or the use of antihypertensive medication
- •- diabetes mellitus, defined as a fasting glucose level above 6,1 mmol/L or the use of antidiabetic medication
- •Additional exclusion criteria for the control group:
- •- hormonal medication
- •- current pregnancy
- •- breastfeeding;Study 3 *The cardiovascular profile in women with a poor ovarian response*
- •For the study group as well as the control group exclusion criteria are:
- •- extirpation of an ovary
- •- cystectomie
- •Both exclusion criteria can be a reason for a decreased ovarian response.
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