A Randomized Trial on Wound Irrigation in Prevention of Surgical Site Infection After Appendectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 179
- 试验地点
- 1
- 主要终点
- Surgical site infection
研究概览
简要总结
Surgical site infection is a common problem after open appendectomy. Irrigation of the surgical wound by topical antibiotics has been devised as a measure to reduce the incidence of wound infection. The present trial aims to assess the efficacy of layer-by-layer wound irrigation with gentamicin-saline solution in prevention of superficial surgical site infection after open appendectomy for acute uncomplicated appendicitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 16 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients of both genders aging between 18 and 65 years who present with acute appendicitis.
- •Patients with perforated appendicitis will be also included.
排除标准
- •Patients with appendicular mass, appendicular abscess, generalized peritonitis.
- •Patients with other causes of acute abdomen as revealed intraoperatively.
- •Patients taking long course of steroid therapy or immunosuppressive treatment,
- •Patients unwilling to participate in the trial.
研究组 & 干预措施
Irrigation
Layer by layer irrigation of the surgical wound with gentamicin-saline solution
干预措施: Irrigation (Procedure)
Control
The surgical wound is closed layer by layer without irrigation
结局指标
主要结局
Surgical site infection
时间窗: 2 months after surgery
The incidence of superficial site infection as detected by clinical examination on follow-up
次要结局
未报告次要终点
研究者
Sameh Emile
Lecturer of general surgery
Mansoura University