Urinary Ascorbyl Peroxide as an Early Biological Marker of Bronchopulmonary Dysplasia in Preterm Infants Less Than 33 Weeks of Gestation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Bronchopulmonary Dysplasia
研究概览
简要总结
Urinary ascorbyl peroxide level in the first week of life will be a good predictor of Bronchopulmonary dysplasia (BPD) in preterm infants less than 33 weeks of gestation.
详细描述
This study uses ascorbyl peroxide as representative of oxidative stress in premature infants on parenteral nutrition and aims to test the correlation of this metabolite and the different major neonatal outcomes 'mainly bronchopulmonary dysplasia).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 23 Weeks 至 32 Weeks（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Preterm infants less than 33 weeks of gestation<
- •Admission to CHU Sainte-JUstien neonatal intensive care unit
- •Receiving Parenteral nutrition during the first week of life
- •Parental consent
排除标准
- •Major congenital anomalies
- •Sever perinatal asphyxia
结局指标
主要结局
Bronchopulmonary Dysplasia
时间窗: 4 Months
To correlate the level of urinary Ascorbyl peroxide and BPD. Full diagnosis and classification (to mild, moderate or severe) is at 36 weeks of corrected age; so even for most premature infants (like 23 weeks of gestation) there will be a need for follow up for less than 4 month to have the final diagnosis at 36 weeks
次要结局
- The redox status (in blood)(First week of life (week 1) and 36 semaines CA)
- Major neonatal outcomes (NEC, ROP, PDA, IVH, PVL)(4 Months)
研究者
Ibrahim Mohamed
Adjunct professor of peditarics, division of neonatology
St. Justine's Hospital