Inducing and Measuring Visual-evoked Potential Plasticity in Humans With Repetitive Transcranial Magnetic Stimulation

University of California, San Francisco2 个研究点分布在 1 个国家目标入组 106 人开始时间: 2023年7月1日最近更新: 2026年6月5日

适应症

干预措施

试验速览

阶段: 不适用
状态: 已完成
发起方: University of California, San Francisco
入组人数: 106
试验地点: 2
主要终点: post-rTMS change in ssVEP Response Amplitude

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The goals of this study are to 1) use EEG steady-state visual evoked potentials as a noninvasive measure of the neuroplasticity induced by repetitive transcranial magnetic stimulation (rTMS), 2) use visual contrast detection paradigms as a behavioral measure of rTMS effects, and 3) to investigate how visual spatial attention augments or suppresses the neuroplastic impact of rTMS. Participants will observe visual stimuli on a screen while allocating their attention to different parts of the visual field and making responses when they observe changes in the visual stimuli. rTMS is performed to visual cortex using MRI-retinotopy neuronavigation. Then the visual task paradigm is performed again.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Crossover
主要目的: Basic Science
盲法: Single (Participant)

盲法说明

Participant is blind to the rTMS target hemisphere, the rTMS stimulation parameters, and the objective of the study

入排标准

年龄范围: 18 Years 至 65 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•Men and women, ages 18 to 65
•Must comprehend English well to ensure adequate comprehension of the EEG and TMS instructions, and of clinical scales
•Left- or Right-handed
•No current or history of neurological disorders
•No seizure disorder or risk of seizures

排除标准

•Those with a contraindication for MRIs (e.g. implanted metal)
•Any unstable medical condition
•History of head trauma with loss of consciousness
•History of seizures
•Neurological or uncontrolled medical disease
•Active substance abuse
•Diagnosis of psychotic or bipolar disorder
•Currently taking medications that substantially reduce seizure threshold (e.g., bupropion, olanzapine, chlorpromazine, lithium)
•Currently pregnant or breastfeeding