NCT02784457已完成2 期
Gonadotropin Releasing Hormone Antagonist in Treatment of Early-onset Severe Ovarian Hyperstimulation Syndrome - a Randomized Controlled Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 84
- 主要终点
- Number of women who needed culdocentesis or paracentesis of the ascitic fluid
研究概览
简要总结
Efficacy of the use of GnRH antagonist in treatment of those who develop early-onset severe ovarian hyperstimulation syndrome and had cancelled embryo transfer
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women who develop early-onset severe ovarian hyperstimulation syndrome after controlled ovarian stimulation using long GnRH agonist protocol and hCG for triggering ovulation.
排除标准
- •Women on short or antagonist protocols.
- •Women who received GnRH agonist for triggering ovulation.
- •Women who had embryo transfer.
研究组 & 干预措施
GnRHant
Active Comparator
women who received GnRH antagonist
干预措施: Cetrorelix (Drug)
结局指标
主要结局
Number of women who needed culdocentesis or paracentesis of the ascitic fluid
时间窗: within 2 weeks of onset
次要结局
- Time to regression of large ovarian size(within 4 weeks of onset of symptoms)
- Number of women who needed hospitalization(within 2 weeks of onset of symptoms)
- Time to regression of nausea/vomiting(within 2 weeks of onset of symptoms)
研究者
Mohammed Faris
Lecturer of Obstetrics and Gynecology
Ain Shams University
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