The Effect of Alginate on Carbohydrate and Fat Digestion in a Mixed Meal - A Pilot Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Concentration of circulating TAG in blood
研究概览
简要总结
This study will investigate the effect of an extract of brown seaweed, called alginate, on fat digestion. The extract has been cooked into sausages and the alginate sausages will be compared to the same sausages that do not contain alginate. People taking part in the study will come to the study centre twice. Once to have the alginate sausage meal or the normal sausage meal and on the second visit they will have the other meal so then end up having had both types of sausages. The level of fat in their blood will be monitored over the four hours after the meal. The rate and amount of fat that moves into the blood after a meal is an indication of the amount of fat digestion. We believe that less fat will be digested and move into the blood when the volunteers eat the alginate sausages compared to the normal sausages.
详细描述
Alginate is an extract of brown seaweed and has been shown to reduce lipase activity in vitro. Lipase is a valid target for anti-obesity products as shown by the pharmaceutical drug orlistat which targets the same enzyme. Reducing the amount of lipase activity will reduce the amount of triacylglycerol (TAG) that will be digested and therefore absorbed and will be seen as a reduction in the level of circulating TAG in the blood. Adding alginate to a range of food products that are simple to include into the diet could help with the management of obesity. In this study, sausages containing alginate have been manufactured for us along with matched control sausage. The circulating TAG in the blood will be measured via fingerpick blood samples every 30 minutes for four hours after the volunteers have eaten either alginate sausages or normal sausages. The volunteers will come for two visits and consume the other sausage meal at the second so they will have had both types of sausage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
neither the researcher or the participant will know if the participant is eating alginate or control sausages
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •pregnant or lactating.
研究组 & 干预措施
Alginate then Control
This group will be given the alginate then the control sausages
干预措施: Alginate Sausage (Dietary Supplement)
Alginate then Control
This group will be given the alginate then the control sausages
干预措施: Control Sausage (Other)
Control then Alginate
This group will be given the control then alginate sausages
干预措施: Alginate Sausage (Dietary Supplement)
Control then Alginate
This group will be given the control then alginate sausages
干预措施: Control Sausage (Other)
结局指标
主要结局
Concentration of circulating TAG in blood
时间窗: 4 hours after the test meal
mmol/L
次要结局
- Concentration of circulating glucose in blood(4 hours after the test meal)