NCT02287207已完成不适用
Effects of Transcranial Direct Current Stimulation on Fine Motor Skills in Parkinson's Disease: a Pilot Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in writing amplitude
研究概览
简要总结
The purpose of this pilot study is to determine the effect of transcranial direct current stimulation (tDCS) on brain activity and fine motor skills in patients with Parkinson's disease compared to healthy controls.
详细描述
The pilot study will involve a double-blind, sham controlled cross-over design where participants will receive anodal and sham tDCS stimulation in a randomized order. Differences in brain activity and fine motor skill performance between groups and after tDCS stimulation will be compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosed with idiopathic PD, according to the UK Brain Bank criteria
- •Hoehn and Yahr (H&Y) stage II in the 'on'-phase of the medication cycle
- •Right dominant PD
排除标准
- •Cognitive impairment (MMSE < 23)
- •Visuo-spatial deficits (measured by the Rey-Osterrieth Complex Figure (ROCF) test)
- •Left-handedness (evaluated by the Edinburgh Handedness scale)
- •Depression
- •Pregnancy
- •Alcohol abuse
- •Aneurysm clips
- •Pacemaker
- •Neurostimulator
- •Implemented defibrillator
- •Magnetically activated implant or device
- •Implemented pump
- •Spinal cord simulator
- •Implemented hearing aid
- •Artificial or prosthetic limb
- •Metal parts in the body
- •Any external or internal metal
- •Artificial heart valve
- •Other implants
- •History of brain surgery
- •Family history of Epilepsy
- •Other contra-indications for tDCS and Transcranial Magnetic Stimulation (TMS)
- •Other neurological, psychiatric or interfering upper limb problems
结局指标
主要结局
Change in writing amplitude
时间窗: post-stimulation (immediately after) and retention (1 week)
Centimeter (cm)
Change in writing velocity
时间窗: post-stimulation (immediately after) and retention (1 week)
Centimeter per second (cm/s)
次要结局
- Change in cortical silent period (cSP)(post-stimulation (immediately after) and retention (1 week))
- Change in speed on the Purdue Pegboard task(post-stimulation (immediately after) and retention (1 week))
- Change in cortical excitability(post-stimulation (immediately after) and retention (1 week))
- Change in Short-Latency Intracortical Inhibition (SICI)(post-stimulation (immediately after) and retention (1 week))
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Effects of tDCS and tUS on Pain Perception in OA of the KneeChronic PainOsteoarthritisNCT02330315Spaulding Rehabilitation Hospital28
进行中（未招募）
不适用
Effects of tDCS and tUS on Pain Perception in OA of the KneeChronic PainOsteoarthritisNCT02723929Spaulding Rehabilitation Hospital64
招募中
不适用
Effects of Transcranial Direct Current Stimulation Versus Sham in Subacromial Pain SyndromeSubacromial Pain SyndromeTranscranial Direct Current StimulationNCT06229925Universidade Federal do Rio Grande do Norte32
撤回
2 期
Transcranial Direct Current Stimulation in a Smoking Cessation TrialNicotine DependenceNCT01710410Centre for Addiction and Mental Health
已完成
不适用
Effect of Cranial Stimulation and Acupuncture on Pain, Functional Capability and Cerebral Function in OsteoarthritisChronic PainOsteoarthritis, KneeNCT01747070Hospital de Clinicas de Porto Alegre60