İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 93
- 试验地点
- 1
- 主要终点
- zonulin levels
研究概览
简要总结
With our study, we aimed to determine whether there is a correlation between zonulin, which plays a crucial role in intestinal barrier function and is implicated in the etiopathogenesis of many chronic and autoimmune diseases, and scattered white spots lesions associated with lymphatic stasis and inflammation in the duodenum.
详细描述
During esophagogastroduodenoscopy (EGD), rarely encountered lesions in the duodenum present as scattered white spots (SWS) on the normal mucosa. Although not fully understood in terms of specific association with any particular disease and clinical significance, some studies have often observed chronic non-specific duodenitis (CND) and intestinal lymphangiectasia (IL) in lesions with SWS. This condition is thought to be related to lymphatic stasis.
Patients included 63 individuals with identified SWS during EGD and 30 patients with a normal appearance of the duodenal mucosa were selected as the control group. SWS lesions were categorized into two groups, grade 1 and grade 2, based on the degree of density and endoscopic appearance. Biopsies were taken from the duodenum, antrum, and corpus. It was examined for IL, CND, giardiasis, and villous atrophy. Venous blood samples were collected from all patients for serum zonulin levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with scattered white patchy lesions in the duodenum on endoscopy and control group patients with normal duodenum on endoscopy.
排除标准
- •active gastroenteritis
- •acute kidney failure
- •chronic kidney failure
- •type-1 diabetes
- •inflammatory bowel disease
- •duodenal ulcer,
- •duodenal tumor
- •autoimmune diseases
结局指标
主要结局
zonulin levels
时间窗: immediately after the procedure
Patients with scattered white spots in the duodenum had blood drawn for zonulin level immediately after the procedure.
次要结局
- Duodenal and gastric pathologic conditions(During the endoscopy)
研究者
Semih Sezer
clinic physician
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital