Early Prediction of Acute Kidney Injury with Cell Cycle Arrest Biomarkers Using Plethesmography Directed Fluid Management in Major Abdominal Surgery

alexandria university faculty of medicine0 个研究点目标入组 40 人开始时间: 2020年1月27日最近更新: 2023年5月29日

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•patients with physical status American Society of Anaesthesiologists (ASA) I and II who will be scheduled for elective major abdominal surgery (is defined as any surgery with intraperitoneal approach performed under general anesthesia and the predictable postoperative hospitalization and length of stay at least two days) with combined general epidural anaesthesia and will be admitted to Alexandria Main University Hospital.

•1- Extremes of age (below 18 years and above 65 years).
•2. Chronic kidney disease.
•3. Perioperative use of nephrotoxic drugs.
•4. Post-renal transplant patient.
•5. Hepatic patient.
•6. Cardiac patients.
•7. Increased intra-abdominal pressure and abdominal laparoscopic surgery.
•8. Diabetes mellitus.
•9. Peripheral arterial occlusive disease.
•10. Pregnancy.
•11. Any plethesmography reading with a corresponding core temperature not within the range of 36 ± 1 °C at any time during the surgery.
•12. Surgical patients at severe nutritional risk by the presence of at least one of (weight loss >10-15% within 6 months, BMI <18.5 kg/m2, preoperative serum albumin <3 g/dl with no evidence of hepatic or renal dysfunction).(21)

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