Investigation of the Combined Effects of Luteinizing Hormone and Follicle-Stimulating Hormone on Metabolic Regulation in Cumulus Cells
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- oxygen consumption rate of mitochodria (%)
研究概览
简要总结
The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear. This prospective study will examine how FSH and LH combined treatment affects cumulus cell energy metabolism. Sixty participants will be divided into two groups receiving either combined therapy or FSH alone. The study will analyze patient characteristics, infertility history, and compare mitochondrial function in cumulus cells to evaluate treatment effectiveness.
详细描述
The impact of combined follicle-stimulating hormone (FSH) and luteinizing hormone (LH) treatment on ovulation stimulation in older infertile women has garnered significant attention in reproductive medicine. While research indicates improved in vitro fertilization (IVF) pregnancy rates in women aged 35-40 receiving combined FSH and LH therapy compared to FSH alone, the underlying mechanisms and effectiveness remain unclear. This prospective study aims to investigate the effects of combined FSH and LH treatment on cumulus cell energy metabolism in infertile women aged 35-40 undergoing IVF treatment. The research will involve 60 participants divided into two equal groups: one receiving combined FSH and LH therapy and the other receiving FSH alone. The study will collect comprehensive data including baseline characteristics, infertility history, ovarian function parameters, and ovulation stimulation cycle outcomes. Additionally, cumulus cells will be collected from both groups to compare their mitochondrial metabolic function. Through this investigation, we seek to understand whether the combined hormone approach can enhance cumulus cell energy metabolism and improve overall ovulation stimulation outcomes in this specific age group. CopyRetryClaude can make mistakes. Please double-check responses.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age 35-40 years
- •BMI 18-30 kg/m2
- •planning to undergo IVF cycles
排除标准
- •Primary ovarian insufficiency
- •history of oophorectomy
- •receiving oocyte donation
- •Chromosome anomaly
- •Congenital uterine anomaly
- •Severe intrauterine adhesion
- •Malignancy
- •Using hormone therapy or supplements in recent 3 months
研究组 & 干预措施
combined FSH and LH
Participants receive combined FSH and LH during controlled ovarian stimulation in IVF cycle
干预措施: FSH and LH (Drug)
FSH alone
Participants receive combined FSH and LH during controlled ovarian stimulation in IVF cycle
干预措施: FSH (Drug)
结局指标
主要结局
oxygen consumption rate of mitochodria (%)
时间窗: through study completion, an average of 3 year
to assess mitocondrial function in cumulus cells
Live birth rate (%)
时间窗: through study completion, an average of 3 year
a viable infant after 24 weeks of gestation
次要结局
- Amount of ATP production (moles/min) of mitochodria(through study completion, an average of 3 year)
- Clinical pregnancy rate (%)(through study completion, an average of 3 year)
研究者
Li-Te Lin
Attending doctor, Department of Obstetrics and Gynecology
Kaohsiung Veterans General Hospital.