NCT04439994已完成不适用
Activation of Plasma miRNA and Proteins as a Result of Acute Experimental Pain
Aalborg University4 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2020年11月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 4
- 主要终点
- Protein expression over time
研究概览
简要总结
In this experiment, the investigators would like to test the following:
- Does acute pain induced by hypertonic injection cause changes in plasma miRNA and protein expression ?
- Can these canges correlate with the development of local hyperalgesia?
- How does the plasma miRNA expression change over a duration of 24 hours post pain induction ?
- Which mRNA targets are potentially affected by acute pain?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women in the age 18-80 years
- •Speak and understand English
排除标准
- •Acute and chronic pain
- •Pregnancy or breastfeeding
- •Drug addiction defined as the use of cannabis, opioids or other drugs
- •Present or previous history of neurological, dermatological, immunological, musculoskeletal, cardiac disorder or mental illnesses that may affect the results (e.g. Neuropathy, muscular pain in the upper extremities, etc.)
- •Lack of ability to cooperate
- •Current use of medications that may affect the trial, such as antipsychotics and pain killers as well as systemic or topical steroids and anti-inflammatory drugs.
- •Skin diseases
- •Consumption of alcohol or painkillers 24 hours before the study days and between these
- •Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials)
结局指标
主要结局
Protein expression over time
时间窗: 24 hours post-injection
Plasma protein evaluation
miRNA expression over time
时间窗: 24 hours post-injection
Plasma miRNA evaluation
次要结局
- Assessment of pain: visual analog scale(20 minutes)
研究者
Silvia Lo Vecchio
Assistant Professor
Aalborg University
研究点 (4)
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